PFDN6 Antikörper (N-Term)

Produktnummer ABIN389346

Zitiert in 3+ Publikationen. Der Kaninchen Polyklonal anti-PFDN6 Antikörper (Klon RB17559) (ABIN389346) detektiert spezifisch PFDN6 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für PFDN6 Antikörper (N-Term) (ABIN389346)

Target: PFDN6 (Prefoldin Subunit 6 (PFDN6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PFDN6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB17559

Produktdetails anti-PFDN6 Antikörper

Bindungsspezifität: AA 6-34, N-Term

Homologie: B, M

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PFDN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-34 amino acids from the N-terminal region of human PFDN6.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-PFDN6 Antikörper (ABIN389346)

Tashiro, Zako, Muto, Itoo, Sörgjerd, Terada, Abe, Miyazawa, Kitamura, Kitaura, Kubota, Maeda, Momoi, Iguchi-Ariga, Kinjo, Ariga: "Prefoldin protects neuronal cells from polyglutamine toxicity by preventing aggregation formation." in: The Journal of biological chemistry, Vol. 288, Issue 27, pp. 19958-72, (2013) (PubMed).

Abe, Takahashi-Niki, Takekoshi, Shimizu, Kitaura, Maita, Iguchi-Ariga, Ariga: "Prefoldin plays a role as a clearance factor in preventing proteasome inhibitor-induced protein aggregation." in: The Journal of biological chemistry, Vol. 288, Issue 39, pp. 27764-76, (2013) (PubMed).

Miyazawa, Tashiro, Kitaura, Maita, Suto, Iguchi-Ariga, Ariga: "Prefoldin subunits are protected from ubiquitin-proteasome system-mediated degradation by forming complex with other constituent subunits." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19191-203, (2011) (PubMed).

Details zu PFDN6

Target: PFDN6 (Prefoldin Subunit 6 (PFDN6))

Andere Bezeichnung: PFDN6

Hintergrund: PFDN6 binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. This protein also binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Molekulargewicht: 14583

Gen-ID: 10471

NCBI Accession: NP_001172110, NP_001252524, NP_001252525, NP_055075

UniProt: O15212

Pathways: Unfolded Protein Response