CD73 Antikörper (N-Term)

Produktnummer ABIN388749

Zitiert in 4+ Publikationen. Der Kaninchen Polyklonal anti-CD73 Antikörper (Klon RB02844) (ABIN388749) detektiert spezifisch CD73 in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für CD73 Antikörper (N-Term) (ABIN388749)

Target: CD73 (NT5E) (5'-Nucleotidase, Ecto (CD73) (NT5E))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD73 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB02844

Produktdetails anti-CD73 Antikörper

Bindungsspezifität: AA 1-30, N-Term

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This CD73 (NT5E) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CD73 (NT5E).

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-CD73 Antikörper (ABIN388749)

Kim, Piao, Pak, Chung, Han, Hong, Jun, Shim, Choi, Kim: "Umbilical cord mesenchymal stromal cells affected by gestational diabetes mellitus display premature aging and mitochondrial dysfunction." in: Stem cells and development, Vol. 24, Issue 5, pp. 575-86, (2015) (PubMed).

Doherty, Bai, Hanidziar, Longhi, Lawlor, Putheti, Csizmadia, Nowak, Cheifetz, Moss, Robson: "CD73 is a phenotypic marker of effector memory Th17 cells in inflammatory bowel disease." in: European journal of immunology, Vol. 42, Issue 11, pp. 3062-72, (2012) (PubMed).

Andrade, Lopez, Noronha, Wink, Borojevic, Margis, Lenz, Battastini, Guma: "Ecto-5'-nucleotidase/CD73 knockdown increases cell migration and mRNA level of collagen I in a hepatic stellate cell line." in: Cell and tissue research, Vol. 344, Issue 2, pp. 279-86, (2011) (PubMed).

Nadri, Soleimani, Mobarra, Amini: "Expression of dopamine-associated genes on conjunctiva stromal-derived human mesenchymal stem cells." in: Biochemical and biophysical research communications, Vol. 377, Issue 2, pp. 423-8, (2008) (PubMed).

Details zu CD73

Target: CD73 (NT5E) (5'-Nucleotidase, Ecto (CD73) (NT5E))

Andere Bezeichnung: CD73 (NT5E)

Hintergrund: Ecto-5-prime-nucleotidase catalyzes conversion at neutral pH of purine 5-prime mononucleotides to nucleosides. The enzyme consists of a dimer of 2 identical 70 kD subunits tethered by a glycosyl phosphatidyl inositol moeity to the exterior plasma membrane surface. The enzyme, a marker of lymphocyte differentiation is associated in deficiency with a variety of immunodeficiency diseases. The preferred substrate is AMP. The NT5 gene has been localized to 6q14-q21 by immunofluorescence and a study of a panel of human x mouse hybrids that contained fragments of chromosome 6 as translocations.

Molekulargewicht: 63368

Gen-ID: 4907

NCBI Accession: NP_001191742, NP_002517

UniProt: P21589

Pathways: Synaptic Membrane, Ribonucleoside Biosynthetic Process