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ATG7 Antikörper (N-Term)

Der Kaninchen Polyklonal Anti-ATG7-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, ATG7 in Proben von Human und Maus zu detektieren. Es sind 3+ Publikationen verfügbar.
Produktnummer ABIN388520

Kurzübersicht für ATG7 Antikörper (N-Term) (ABIN388520)

Target

Alle ATG7 Antikörper anzeigen
ATG7 (ATG7 Autophagy Related 7 (ATG7))

Reaktivität

  • 113
  • 41
  • 27
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus

Wirt

  • 102
  • 15
  • 2
Kaninchen

Klonalität

  • 92
  • 27
Polyklonal

Konjugat

  • 70
  • 7
  • 7
  • 6
  • 4
  • 4
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ATG7 Antikörper ist unkonjugiert

Applikation

  • 99
  • 53
  • 45
  • 26
  • 21
  • 14
  • 14
  • 14
  • 13
  • 12
  • 5
  • 4
  • 3
  • 2
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

RB7467
  • Bindungsspezifität

    • 15
    • 15
    • 10
    • 9
    • 6
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 22-51, N-Term

    Homologie

    Rat

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This ATG7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-51 amino acids from the N-terminal region of human ATG7.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    Haltbarkeit

    6 months
  • Wang, Hu, Sun, Zhuo, He, Wang, Yan, Liu, Luan, Dai, Yang, Huang, Zhou, Zhang, Zhai: "Down-regulation of Risa improves insulin sensitivity by enhancing autophagy." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 30, Issue 9, pp. 3133-45, (2017) (PubMed).

    Yang, Zhao, Mei, Jiang, Geng, Li, Yao, Liu, Kong, Cao: "HMGA2 plays an important role in Cr (VI)-induced autophagy." in: International journal of cancer, Vol. 141, Issue 5, pp. 986-997, (2017) (PubMed).

    Chiu, Kulp, Soni, Wang, Gunn, Schlesinger, Chen: "Eradication of intracellular Salmonella enterica serovar Typhimurium with a small-molecule, host cell-directed agent." in: Antimicrobial agents and chemotherapy, Vol. 53, Issue 12, pp. 5236-44, (2009) (PubMed).

  • Target

    ATG7 (ATG7 Autophagy Related 7 (ATG7))

    Andere Bezeichnung

    ATG7

    Hintergrund

    Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG7 functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. APG3L is an E2-like conjugating enzyme facilitating covalent binding of APG8 (MAP1LC3) to phosphatidylethanolamine (PE). APG7 (an E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with APG3. Formation of the PE conjugate is essential for autophagy.

    Molekulargewicht

    77960

    Gen-ID

    10533

    NCBI Accession

    NP_001129503, NP_001138384, NP_006386

    UniProt

    O95352

    Pathways

    Response to Water Deprivation, Autophagie
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