Kdm6b Antikörper (AA 954-987)

Produktnummer ABIN387864

Dieses Anti-Kdm6b-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Kdm6b in WB. Geeignet für Human und Maus. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für Kdm6b Antikörper (AA 954-987) (ABIN387864)

Target: Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Kdm6b Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB10080

Produktdetails anti-Kdm6b Antikörper

Bindungsspezifität: AA 954-987

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This Mouse JMJD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 954-987 amino acids from the Central region of mouse JMJD3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-Kdm6b Antikörper (ABIN387864)

Shaw, Martin: "Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes." in: EMBO reports, Vol. 10, Issue 8, pp. 881-6, (2009) (PubMed).

Details zu Kdm6b

Target: Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

Andere Bezeichnung: JMJD3

Hintergrund: Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.

Molekulargewicht: 176355

Gen-ID: 216850

NCBI Accession: NP_001017426

UniProt: Q5NCY0

Pathways: Warburg Effekt