CD44 Antikörper (Biotin)

Produktnummer ABIN376015

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CD44 in FACS, IHC, IHC (p) und IP. Er zeigt eine Reaktivität gegenüber Human und wurde in 1 Publikation erwähnt.

Kurzübersicht für CD44 Antikörper (Biotin) (ABIN376015)

Target: CD44

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD44 Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Klon: F10-44-2

Produktdetails anti-CD44 Antikörper (Biotin)

Spezifität: Human/Ma's Night Monkey CD44, Mr 80 - 95 kDa

Produktmerkmale: Mouse Anti-Human CD44-BIOT

Aufreinigung: Purified

Immunogen: Purified T cells from human lymph nodes

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Working Dilution:
10 µL/10^6 cells
Representative data are included in this product insert.

Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Handhabung: Protect conjugated products from light.
Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: 4 °C

Referenzen für anti-CD44 Antikörper (Biotin) (ABIN376015)

Caeser, Di Re, Krupka, Gao, Lara-Chica, Dias, Cooke, Fenner, Usheva, Runge, Beer, Eldaly, Pak, Park, Vassiliou, Huntly, Mupo, Bashford-Rogers, Hodson: "Genetic modification of primary human B cells to model high-grade lymphoma." in: Nature communications, Vol. 10, Issue 1, pp. 4543, (2020) (PubMed).

Details zu CD44

Target: CD44

Andere Bezeichnung: CD44

Hintergrund: CD44, also known as phagocytic glycoprotein-1 (Pgp-1) and the receptor for hyaluronate, exists as a large number of different isoforms resulting from alternative RNA splicing. The major isoform expressed on lymphocytes, myeloid cells and erythrocytes is a glycosylated type I transmembrane protein. Other variable isoforms containing glycosaminoglycans have molecular weights ranging from 110 to 250 kDa and are widely expressed on hematopoietic and non-hematopoietic cells. CD44 contributes to the adhesion of leukocytes to endothelial cells, stromal cells and the extracellular matrix. It also plays a functional role in cell migration, lymphocyte homing and adhesion during hematopoiesis and lymphocyte activation.

Pathways: Glycosaminoglycan Metabolic Process, Autophagie, Negative Regulation of intrinsic apoptotic Signaling