FGF23 Antikörper (Internal Region)

Produktnummer ABIN375198

Produktdetails anti-FGF23 Antikörper

Target: FGF23 (Fibroblast Growth Factor 23 (FGF23))

Bindungsspezifität: Internal Region

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser FGF23 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequenz: C-RHTRSAEDDS ERD

Spezifität: This antibody recognizes FGF23.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography

Immunogen: Synthetic peptide from the internal region of Human FGF23 (NP_065689.1) Genename: FGF23

Anwendungsinformationen

Applikationshinweise: ELISA: 1/32000. Western Blot: 0.5 - 1.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu FGF23

Target: FGF23 (Fibroblast Growth Factor 23 (FGF23))

Andere Bezeichnung: FGF23 (FGF23 Produkte)

Synonyme: FGF23 antikoerper, ADHR antikoerper, FGFN antikoerper, HPDR2 antikoerper, HYPF antikoerper, PHPTC antikoerper, fibroblast growth factor 23 antikoerper, fgf23 antikoerper, FGF23 antikoerper, Fgf23 antikoerper

Hintergrund: Defects in FGF23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) [MIM:193100]. ADHR is characterized by low serum phosphorus concentrations, rickets, osteomalacia, leg deformities, short stature, bone pain and dental abscesses. Defects in FGF23 are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC) [MIM:211900]. HFTC is a severe autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.Synonyms: FGF-23, Fibroblast growth factor 23, HYPF, Phosphatonin, Tumor-derived hypophosphatemia-inducing factor

Molekulargewicht: 27.9 kDa (NP_065689.1).

Gen-ID: 8074

NCBI Accession: NP_065689

UniProt: Q9GZV9

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Negative Regulation of Hormone Secretion