ERN1 Antikörper (Internal Region)

Produktnummer ABIN375027

Produktdetails anti-ERN1 Antikörper

Target: ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser ERN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody reacts to ERN1 / IRE1a.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat, Canine, Bovine and Swine.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Immunogen: Peptide with sequence C-PNAHGKIKAMISD, from the internal region of the protein sequence

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/8000. Western Blot: 0.03 - 0.1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-ERN1 Antikörper (ABIN375027)

Lai, Li, Kuang, Cui, Yang, Sun, Liu, Chen, Yan, Wen: "PKCδ silencing alleviates saturated fatty acid induced ER stress by enhancing SERCA activity." in: Bioscience reports, Vol. 37, Issue 6, (2018) (PubMed).

Yokouchi, Hiramatsu, Hayakawa, Okamura, Du, Kasai, Takano, Shitamura, Shimada, Yao, Kitamura: "Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response." in: The Journal of biological chemistry, Vol. 283, Issue 7, pp. 4252-60, (2008) (PubMed).

Details zu ERN1

Target: ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))

Andere Bezeichnung: ERN1 / IRE1 (ERN1 Produkte)

Synonyme: IRE1 antikoerper, IRE1P antikoerper, IRE1a antikoerper, hIRE1p antikoerper, 9030414B18Rik antikoerper, AI225830 antikoerper, C85377 antikoerper, Ire1a antikoerper, Ire1alpha antikoerper, Ire1p antikoerper, RGD1559716 antikoerper, Ern1 antikoerper, Ire1 antikoerper, Ire1b antikoerper, sb:eu1005 antikoerper, zgc:109932 antikoerper, endoplasmic reticulum to nucleus signaling 1 antikoerper, endoplasmic reticulum to nucleus signaling 2 antikoerper, endoplasmic reticulum (ER) to nucleus signalling 1 antikoerper, serine/threonine-protein kinase/endoribonuclease IRE1 antikoerper, endoplasmic reticulum (ER) to nucleus signalling 2 antikoerper, ERN1 antikoerper, ERN2 antikoerper, Ern1 antikoerper, LOC524719 antikoerper, Ern2 antikoerper, ern1 antikoerper

Hintergrund: IRE1 is involved in myo inositol biosynthesis and is implicated as the sensor of unfolded proteins in the ER that initiates transmittance of the unfolded protein signal from the ER to the nucleus. It is a transmembrane protein that has both serine threonine kinase and endoribonuclease activities. Null mutants are viable, but IRE1 is essential for viability under stress conditions that cause unfolded proteins to accumulate in the ER.Synonyms: Endoplasmic reticulum-to-nucleus signaling 1, IRE1a, IRE1p, Inositol-requiring protein 1, Ire1-alpha, Serine/threonine-protein kinase/endoribonuclease IRE1

Gen-ID: 2081

NCBI Accession: NP_001424

UniProt: O75460

Pathways: ER-Nucleus Signaling, Unfolded Protein Response