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ERN1 Antikörper (C-Term)

ERN1 Reaktivität: Human, Maus, Ratte WB, IF, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN500048
  • Target Alle ERN1 Antikörper anzeigen
    ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))
    Bindungsspezifität
    • 16
    • 16
    • 14
    • 13
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 102
    • 77
    • 73
    • 16
    • 1
    Human, Maus, Ratte
    Wirt
    • 106
    • 4
    • 3
    • 1
    Kaninchen
    Klonalität
    • 107
    • 7
    Polyklonal
    Konjugat
    • 32
    • 11
    • 10
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser ERN1 Antikörper ist unkonjugiert
    Applikation
    • 81
    • 44
    • 29
    • 26
    • 26
    • 10
    • 9
    • 7
    • 6
    • 5
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Spezifität
    IRE1p antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human IRE1p.
    Aufreinigung
    Affinity Chromatography purified via peptide column
    Immunogen
    16 amino acid synthetic peptide from near the carboxy terminus of Human IRE1p
    Isotyp
    IgG
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  • Applikationshinweise
    ELISA. Western Blot: 1 - 2 μg/mL. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))
    Andere Bezeichnung
    ERN1 / IRE1 (ERN1 Produkte)
    Synonyme
    IRE1 antikoerper, IRE1P antikoerper, IRE1a antikoerper, hIRE1p antikoerper, 9030414B18Rik antikoerper, AI225830 antikoerper, C85377 antikoerper, Ire1a antikoerper, Ire1alpha antikoerper, Ire1p antikoerper, RGD1559716 antikoerper, Ern1 antikoerper, Ire1 antikoerper, Ire1b antikoerper, sb:eu1005 antikoerper, zgc:109932 antikoerper, endoplasmic reticulum to nucleus signaling 1 antikoerper, endoplasmic reticulum to nucleus signaling 2 antikoerper, endoplasmic reticulum (ER) to nucleus signalling 1 antikoerper, serine/threonine-protein kinase/endoribonuclease IRE1 antikoerper, endoplasmic reticulum (ER) to nucleus signalling 2 antikoerper, ERN1 antikoerper, ERN2 antikoerper, Ern1 antikoerper, LOC524719 antikoerper, Ern2 antikoerper, ern1 antikoerper
    Hintergrund
    Accumulation of malfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94 (1,2). These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 (3,4) but ER stress causes their dissociation. This allows IRE1p, a serine-threonine protein kinase to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation (5). Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER (6). Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.Synonyms: Endoplasmic reticulum-to-nucleus signaling 1, IRE1a, IRE1p, Inositol-requiring protein 1, Ire1-alpha, Serine/threonine-protein kinase/endoribonuclease IRE1
    Gen-ID
    2081
    UniProt
    O75460
    Pathways
    ER-Nucleus Signaling, Unfolded Protein Response
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