PHLPP2 Antikörper (C-Term)

Produktnummer ABIN374772

Produktdetails anti-PHLPP2 Antikörper

Target: PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser PHLPP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody reacts to PHLPP2.

Aufreinigung: Affinity chromatography

Immunogen: Peptide with sequence C-PHEEDRTEPPEEFD, from the C Terminus of the protein sequence

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/32000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PHLPP2

Target: PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))

Andere Bezeichnung: PHLPP2 (PHLPP2 Produkte)

Synonyme: PHLPPL antikoerper, phlppl antikoerper, AI481772 antikoerper, C130044A18Rik antikoerper, Phlppl antikoerper, RGD1562857 antikoerper, PH domain and leucine rich repeat protein phosphatase 2 antikoerper, PH domain and leucine rich repeat protein phosphatase 2 S homeolog antikoerper, PHLPP2 antikoerper, phlpp2.S antikoerper, phlpp2 antikoerper, Phlpp2 antikoerper

Hintergrund: PHLPP2 contains 21 LRR (leucine rich) repeats, 1 PH domain and 1 PP2C like domain. It is a protein phosphatase that specifically mediates dephosphorylation of AKT1 Ser 473, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro and antiapoptotic genes. Dephosphorylation of Ser 473 of AKT1 triggers apoptosis and decrease cell proliferation. PHLPP2 also controls the phosphorylation of AKT3. It binds 2 manganese ions per subunit. There are 3 named isoforms produced by alternative splicing.Synonyms: KIAA0931, PH domain leucine-rich repeat-containing protein phosphatase 2, PH domain leucine-rich repeat-containing protein phosphatase-like, PHLPP-like, PHLPPL

Gen-ID: 23035

NCBI Accession: NP_055835

UniProt: Q6ZVD8

Pathways: PI3K-Akt Signalweg, Fc-epsilon Rezeptor Signalübertragung