PAK1 Antikörper (Internal Region)

Produktnummer ABIN374720

Der Ziege Polyklonal anti-PAK1 Antikörper wird verwendet zum Nachweis von PAK1 in Proben von Human, Ratte, Maus und Hund. Er wurde validiert für WB.

Kurzübersicht für PAK1 Antikörper (Internal Region) (ABIN374720)

Target: PAK1 (P21-Activated Kinase 1 (PAK1))

Reaktivität: Human, Ratte, Maus, Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser PAK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PAK1 Antikörper

Bindungsspezifität: Internal Region

Spezifität: This antibody reacts to PAK1. No cross-reactivity exptected with PAK3.

Kreuzreaktivität (Details): Species reactivity (expected):Canine.
Species reactivity (tested):Human, Mouse, Rat.

Aufreinigung: Affinity chromatography

Immunogen: Peptide with sequence C-NTEKQKKKPKMSDE, from the internal region of the protein sequence

Anwendungsinformationen

Applikationshinweise: ELISA: 1/4000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PAK1

Target: PAK1 (P21-Activated Kinase 1 (PAK1))

Andere Bezeichnung: PAK1

Hintergrund: The serine/threonine kinase Pak1 is an effector of small Rho GTPases, Rac1 and Cdc42. Pak1 complex specifically with Rac1 and Cdc42 in their active GTP bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. It plays an important role in the regulation of cell morphogenesis, motility, mitosis, and angiogenesis and has been implicated in the progression of many cancers.Synonyms: Alpha-PAK, PAK 1, PAK alpha, PAK-1, Serine/threonine-protein kinase PAK 1, p21-activated kinase 1, p65-PAK

Gen-ID: 5058

NCBI Accession: NP_001122092

UniProt: Q13153

Pathways: MAPK Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Embryonic Body Morphogenesis