UNC13D Antikörper (Internal Region)

Produktnummer ABIN374716

Produktdetails anti-UNC13D Antikörper

Target: UNC13D (Unc-13 Homolog D (UNC13D))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser UNC13D Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody reacts to Munc13-4 / UNC13D.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat, Canine.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Immunogen: Peptide with sequence C-ETQKHKKDLHPLFD, from the internal region of the protein sequence

Anwendungsinformationen

Applikationshinweise: ELISA: 1/128000. Western Blot: 1 - 3 μg/mL. Immunohistochemistry on paraffin sections: 2.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu UNC13D

Target: UNC13D (Unc-13 Homolog D (UNC13D))

Andere Bezeichnung: UNC13D (UNC13D Produkte)

Hintergrund: Secretion of the contents of cytolytic granules at the immunologic synapse is a highly regulated process essential for lymphocyte cytotoxicity. This process requires the rapid transfer of perforin containing lytic granules to the target cell interface, followed by their docking and fusion with the plasma membrane. Munc 13-4 localises with cytotoxic granules at the immunologic synapse. Munc 13-4 is essential for the priming step of cytolytic granule secretion preceding vesicle membrane fusion. There are two named isoforms.Synonyms: Munc13-4, Protein unc-13 homolog D

Gen-ID: 201294, 9606

UniProt: Q70J99

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process