ADAM8 Antikörper (C-Term)

Produktnummer ABIN374195

Der Ziege Polyklonal anti-ADAM8 Antikörper wird verwendet zum Nachweis von ADAM8 in Proben von Human. Er wurde validiert für WB und EIA.

Kurzübersicht für ADAM8 Antikörper (C-Term) (ABIN374195)

Target: ADAM8 (ADAM Metallopeptidase Domain 8 (ADAM8))

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser ADAM8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-ADAM8 Antikörper

Bindungsspezifität: C-Term

Sequenz: C-QRKQGAGAPT AP

Spezifität: This antibody is expected to recognise isoform 1 and 3 (NP_001100.3 and NP_001157962.1).

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide from C Terminus of the protein sequence according to NP_001100.3, NP_001157962.1. Genename: ADAM8

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: Limit dilution 1: 1000. Western blot: 1-3 μg/mL. Approx 90 kDa band seen in Human Brain lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu ADAM8

Target: ADAM8 (ADAM Metallopeptidase Domain 8 (ADAM8))

Andere Bezeichnung: CD156a / ADAM8

Hintergrund: Members of ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. The extracellular region of ADAM8 shows significant amino acid sequence homology to hemorrhagic snake venom proteins, including the metalloprotease and disintegrin domains. The expression of ADAM8 is upregulated by retinoic acid and vitamin D3. The function of ADAM8 is still poorly understood. ADAM8 has been shown to stimulate osteoclasts, and to be produced by bone marrow cultures stimulated by vitamin-D. ADAM8 is involved in protein processing at the cell surface and is also thought to act as a leukocyte differentiation marker.Synonyms: Cell surface antigen MS2, Disintegrin and metalloproteinase domain-containing protein 8, MS2

Molekulargewicht: 88.8 kDa according to NP_001100.3.

Gen-ID: 101

NCBI Accession: NP_001100

UniProt: P78325

Pathways: Activation of Innate immune Response, M Phase