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APEX1 Antikörper (N-Term)
APEX1
Reaktivität: Human, Rind (Kuh), Schwein, Hund
WB, IHC (p), EIA
Wirt: Ziege
Polyclonal
unconjugated
Produktdetails anti-APEX1 Antikörper
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Target
Alle APEX1 Antikörper anzeigen
APEX1
(Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
Bindungsspezifität
Alle Epitope für APEX1 Antikörper
N-Term
Reaktivität
Alle Reaktivitäten für APEX1 Antikörper
Human, Rind (Kuh), Schwein, Hund
Wirt
Alle Wirte für APEX1 Antikörper
Ziege
Klonalität
Alle Klonalitäten für APEX1 Antikörper
Polyklonal
Konjugat
Alle Konjugate für APEX1 Antikörper
Dieser APEX1 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für APEX1 Antikörper
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
Sequenz
PKRGKKGAVA EDGD-C
Spezifität
This antibody detects APEX1 / REF-1 at N-term.
Kreuzreaktivität (Details)
Species reactivity (expected):Canine (Dog), Pig, Cow. Species reactivity (tested):Human.
Aufreinigung
Immunoaffinity Chromatography
Immunogen
Synthetic peptide from the N-Terminus of Human APEX1 / APE1 (NP_001632.2). Genename: APEX1
Top Product
Discover our top product APEX1 Primärantikörper
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Anwendungsinformationen
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Applikationshinweise
Peptide ELISA: Limit dilution 1: 32000. Western blot: 0.5-2 μg/mL. Approx 35 kDa band observed in Human epidermoid fibroblastA431 and Human cervix epitheloid fibroblast HeLa lysates (calculated MW of 35.5 kDaaccording to NP_001632.2, NP_542379.1, NP_542380.1. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
0.5 mg/mL
Buffer
Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Details zu APEX1
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Target
APEX1
(Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
Andere Bezeichnung
APEX1 / REF-1 (APEX1 Produkte )
Synonyme
apex1 antikoerper, MGC76280 antikoerper, MGC79645 antikoerper, MGC78928 antikoerper, APE antikoerper, APE1 antikoerper, APEN antikoerper, APEX antikoerper, APX antikoerper, HAP1 antikoerper, REF1 antikoerper, Apex antikoerper, REF-1 antikoerper, BAP1 antikoerper, apex1a antikoerper, hm:zehn1532 antikoerper, wu:fc13d11 antikoerper, zgc:66204 antikoerper, Ref-1 antikoerper, apurinic/apyrimidinic endodeoxyribonuclease 1 antikoerper, APEX nuclease (multifunctional DNA repair enzyme) 1 antikoerper, APEX nuclease (multifunctional DNA repair enzyme) 1 L homeolog antikoerper, DNA-(apurinic or apyrimidinic site) lyase antikoerper, apurinic/apyrimidinic endonuclease 1 antikoerper, APEX1 antikoerper, apex1 antikoerper, apex1.L antikoerper, CNG03640 antikoerper, CNH01280 antikoerper, nth antikoerper, Spirs_4119 antikoerper, Palpr_0103 antikoerper, Apex1 antikoerper
Hintergrund
Apurinic / apyrimidinic endonuclease (APE1 or REF1) is responsible for the incision of DNA basic sites during base excision repair. It has also been shown to stimulate the DNA binding activity of numerous transcription factors that are involved in cancer promotion and progression. Alterations in APE1 levels have been described in some cancers. APE1 is part of the cellular response to oxidative stress and protects cells from the genotoxic and cytotoxic effect of oxidizing agents.Synonyms: APE, APEN, APEX, APEX nuclease, APX, Apurinic-apyrimidinic endonuclease 1, HAP1, Protein REF-1, REF1
Gen-ID
328
NCBI Accession
NP_001632
UniProt
P27695
Pathways
DNA Reparatur , Chromatin Binding , Cell RedoxHomeostasis , Smooth Muscle Cell Migration , Positive Regulation of Response to DNA Damage Stimulus
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