Der Kaninchen Polyklonal Anti-RPS6KA3-Antikörper wurde für WB validiert. Er ist geeignet, RPS6KA3 in Proben von Human, Maus, Ratte, Rind (Kuh), Hund und Huhn zu detektieren.
Western blot: 1/1,000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
-20 °C
Informationen zur Lagerung
Store the antibody undiluted (in aliquots) at-20 °C.
Target
RPS6KA3
(Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3))
Andere Bezeichnung
RPS6KA3 / RSK2
Hintergrund
The p90 Ribosomal S6 kinases (RSK1-4) are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. The loss of RSK2 activity in humans leads to Coffin-Lowry syndrome, which is characterized by mental retardation and growth deficits (Hanauer and Young, 2002). Recent work suggests that RSK2 exerts a tonic regulation on G-protein coupled signaling (Sheffler et al., 2006).Synonyms: ISPK-1, ISPK1, MAPKAPK-1b, MAPKAPK1, RSK-2, Ribosomal S6 kinase 2, Ribosomal protein S6 kinase alpha-3, S6K-alpha-3, p90RSK3