MAP2 Antikörper

Produktnummer ABIN372661

Produktdetails anti-MAP2 Antikörper

Target: MAP2 (Microtubule-Associated Protein 2 (MAP2))

Reaktivität: Human, Maus, Ratte, Rind (Kuh)

Wirt: Huhn

Klonalität: Polyklonal

Konjugat: Dieser MAP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: This antibody is specific for the ~280k MAP2 protein.

Kreuzreaktivität (Details): Species reactivity (tested):Bovine, Human, Mouse and Rat.

Aufreinigung: Ig Fraction

Immunogen: Bovine MAP2 isolated from brain by the GTP microtubule cycling method.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Western blot: 1/20,000. Immunohistochemistry. Immunofluorescence: 1/2,500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted (in aliquots) at-20 °C.

Referenzen für anti-MAP2 Antikörper (ABIN372661)

Klüssendorf, Song, Schau, Morellini, Dityatev, Koliwer, Kreienkamp: "The Golgi-Associated PDZ Domain Protein Gopc/PIST Is Required for Synaptic Targeting of mGluR5." in: Molecular neurobiology, Vol. 58, Issue 11, pp. 5618-5634, (2022) (PubMed).

Jacquemet, Paatero, Carisey, Padzik, Orange, Hamidi, Ivaska: "FiloQuant reveals increased filopodia density during breast cancer progression." in: The Journal of cell biology, Vol. 216, Issue 10, pp. 3387-3403, (2017) (PubMed).

Details zu MAP2

Target: MAP2 (Microtubule-Associated Protein 2 (MAP2))

Andere Bezeichnung: MAP-2 (MAP2 Produkte)

Synonyme: MAP2A antikoerper, MAP2B antikoerper, MAP2C antikoerper, MAP2R antikoerper, Mtap2 antikoerper, MAP-2 antikoerper, Mtap-2 antikoerper, xmap2 antikoerper, MGC53131 antikoerper, a730034c02 antikoerper, zgc:103474 antikoerper, zgc:113974 antikoerper, microtubule associated protein 2 antikoerper, microtubule-associated protein 2 antikoerper, microtubule associated protein 2 S homeolog antikoerper, MAP2 antikoerper, Map2 antikoerper, map2.S antikoerper, map2 antikoerper

Hintergrund: Microtubules are 25nm diameter protein rods found in most kinds of eukaryotic cells. They are polymerized from a dimeric subunit made of one a subunit and one b tubulin subunit. Microtubules are associated with a family of proteins called microtubule associated proteins (MAPs), which includes the protein tau and a group of proteins referred to as MAP1, MAP2, MAP3, MAP4 and MAP5 (Kindler & Gardner 1994). MAP2 is made up of two ~280 kDa apparent molecular weight bands referred to as MAP2a and MAP2b. A third lower molecular weight form, usually called MAP2c, corresponds to a pair of protein bands running at ~70 kDa on SDS-PAGE gels. All these MAP2 forms are derived from a single gene by alternate transcription, and all share a C-terminal sequence which includes either three or four microtubule binding peptide sequences, which are very similar to those found in the related microtubule binding protein tau. MAP2 isoforms are expressed only in neuronal cells and specifically in the perikarya and dendrites of these cells. MAP2 has been recently shown to be the specific receptor for the neurosteroid pregnenolone (Fontaine-Lenore V. et al., 2006).Synonyms: MAP2, Microtubule-associated protein 2, Neuronal Marker

Gen-ID: 4133

NCBI Accession: NP_002365

UniProt: P11137