APEX1 Antikörper

Produktnummer ABIN363379

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch APEX1 in WB, IHC, IF, ICC, ChIP, IP und Neut. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte und Kaninchen.

Kurzübersicht für APEX1 Antikörper (ABIN363379)

Target: APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))

Reaktivität: Human, Maus, Ratte, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APEX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Chromatin Immunoprecipitation (ChIP), Immunoprecipitation (IP), Neutralization (Neut)

Produktdetails anti-APEX1 Antikörper

Spezifität: Reacts with human ~37 kDa APE-1 protein

Kreuzreaktivität: Maus, Kaninchen, Ratte (Rattus)

Kreuzreaktivität (Details): Cross reacts with proteins from mouse, rat and rabbit.

Aufreinigung: Antigen affinity purified

Immunogen: Affinity purified human Apurinic/Apyrimidinic Endonuclease (APE/ref-1) fusion protein

Anwendungsinformationen

Applikationshinweise:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
- IHC: 1/1 000 - WB : 1/1 000 - B/N: 50-200 Molar excess - ChIP: 1/10-1/500 - ICC/IF: 1/50-1/200 - IP: 7 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Tris-glycine, NaCl 150 mM buffer, Sodium azide 0.05 %

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C/-80 °C

Informationen zur Lagerung: Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.

Details zu APEX1

Target: APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))

Andere Bezeichnung: DNA-(Apurinic Or Apyrimidinic Site) Lyase (APE-1)

Hintergrund: Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents.

Gen-ID: 328

Pathways: DNA Reparatur, Chromatin Binding, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus