APEX1 Antikörper

Produktnummer ABIN363379

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch APEX1 in WB, IHC, IF, ICC, ChIP, IP und Neut. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte und Kaninchen.

Kurzübersicht für APEX1 Antikörper (ABIN363379)

Target: APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))

Reaktivität: Human, Maus, Ratte, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APEX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Chromatin Immunoprecipitation (ChIP), Immunoprecipitation (IP), Neutralization (Neut)

Produktdetails anti-APEX1 Antikörper

Spezifität: Reacts with human ~37 kDa APE-1 protein

Kreuzreaktivität: Maus, Kaninchen, Ratte (Rattus)

Kreuzreaktivität (Details): Cross reacts with proteins from mouse, rat and rabbit.

Aufreinigung: Antigen affinity purified

Immunogen: Affinity purified human Apurinic/Apyrimidinic Endonuclease (APE/ref-1) fusion protein

Anwendungsinformationen

Applikationshinweise:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
- IHC: 1/1 000 - WB : 1/1 000 - B/N: 50-200 Molar excess - ChIP: 1/10-1/500 - ICC/IF: 1/50-1/200 - IP: 7 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Tris-glycine, NaCl 150 mM buffer, Sodium azide 0.05 %

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C/-80 °C

Informationen zur Lagerung: Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.

Details zu APEX1

Target: APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))

Andere Bezeichnung: DNA-(Apurinic Or Apyrimidinic Site) Lyase (APE-1)

Hintergrund: Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents.

Gen-ID: 328

Pathways: DNA Reparatur, Chromatin Binding, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus