NFKBIB Antikörper (pSer23)
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- Target Alle NFKBIB Antikörper anzeigen
- NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))
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Bindungsspezifität
- pSer23
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser NFKBIB Antikörper ist unkonjugiert
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Applikation
- Immunohistochemistry (IHC)
- Spezifität
- The antibody detects endogenous level of IkB-b only when phosphorylated at serine 23.
- Aufreinigung
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.
- Immunogen
- Peptide sequence around phosphorylation site of pSer23 (L-G-S (p) -L-G) derived from Human IkB-b. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
- Isotyp
- IgG
- Top Product
- Discover our top product NFKBIB Primärantikörper
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- Applikationshinweise
- Immunohistochemistry: 1:50-1:100
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- Target
- NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))
- Andere Bezeichnung
- IkappaB-beta (NFKBIB Produkte)
- Synonyme
- NFKBIB antikoerper, IKB-beta antikoerper, IKappaBbeta antikoerper, IkB antikoerper, IkBb antikoerper, IKBB antikoerper, TRIP9 antikoerper, NFKB inhibitor beta antikoerper, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta antikoerper, NFKBIB antikoerper, Nfkbib antikoerper
- Hintergrund
- Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
- Molekulargewicht
- 48 kDa
- NCBI Accession
- NP_001001
- UniProt
- Q15653
- Pathways
- NF-kappaB Signalweg, Activation of Innate immune Response, Maintenance of Protein Location, Toll-Like Receptors Cascades
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