IGF1R Antikörper (AA 1159-1163)

Produktnummer ABIN362636

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch IGF1R in WB, IHC und IF. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für IGF1R Antikörper (AA 1159-1163) (ABIN362636)

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IGF1R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-IGF1R Antikörper

Bindungsspezifität: AA 1159-1163

Spezifität: The antibody detects endogenous level of total IGF-1R protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.

Immunogen: Peptide sequence around AA 1159-1163 (D-I-Y-E-T) derived from Human IGF-1R . Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
Immunofluorescence: 1:100-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Referenzen für anti-IGF1R Antikörper (ABIN362636)

Haghir, Rezaee, Nomani, Sankian, Kheradmand, Hami: "Sexual dimorphism in expression of insulin and insulin-like growth factor-I receptors in developing rat cerebellum." in: Cellular and molecular neurobiology, Vol. 33, Issue 3, pp. 369-77, (2013) (PubMed).

Yamamoto, Oshima, Yoshihara, Nishi, Arai, Inui, Kaneko, Nozawa, Adachi, Rino, Masuda, Imada: "Clinical significance of immunohistochemical expression of insulin-like growth factor-1 receptor and matrix metalloproteinase-7 in resected non-small cell lung cancer." in: Experimental and therapeutic medicine, Vol. 3, Issue 5, pp. 797-802, (2012) (PubMed).

Details zu IGF1R

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Andere Bezeichnung: IGF-1R

Hintergrund: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.

Molekulargewicht: 95 kDa

NCBI Accession: NP_000866

UniProt: P08069

Pathways: RTK Signalweg, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagie