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Nitrotyrosine Antikörper

AA, ELISA, FACS, ICC, IF, IHC, IP, WB Wirt: Maus Monoclonal 39B6 unconjugated
Pubmed (9 Referenzen)
Produktnummer ABIN361658
$530.40
Zzgl. Versandkosten $45.00
Lieferung in 3 bis 4 Werktagen
  • Target Alle Nitrotyrosine Antikörper anzeigen
    Nitrotyrosine
    Reaktivität
    Bitte anfragen
    Wirt
    • 32
    • 26
    • 3
    Maus
    Klonalität
    • 31
    • 29
    Monoklonal
    Konjugat
    • 30
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Nitrotyrosine Antikörper ist unkonjugiert
    Applikation
    • 46
    • 28
    • 25
    • 22
    • 21
    • 15
    • 13
    • 13
    • 11
    • 11
    • 10
    • 9
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Antibody Array (AA), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
    Spezifität
    Recognizes 3-nitrotyrosine moieties. No detectable cross-reactivity with non-nitrated tyrosine. Not species specific.
    Aufreinigung
    Protein G Purified
    Immunogen
    3-(4-hydroxy-3-nitrophenylacetamido) propionic acid-bovine serum albumin
    Klon
    39B6
    Isotyp
    IgG2a
  • Applikationshinweise
    • WB (1:1400)
    • IHC (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    0.7 μg/ml of ABIN361657 was sufficient for detection of 5 μg SIN-1 treated BSA by Western Blot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C
  • Wert, Velez, Cross, Wagner, Teoh-Fitzgerald, Buettner, McAnany, Olivier, Tsang, Harper, Domann, Bassuk, Mahajan: "Extracellular superoxide dismutase (SOD3) regulates oxidative stress at the vitreoretinal interface." in: Free radical biology & medicine, Vol. 124, pp. 408-419, (2019) (PubMed).

    Matsui, Nakashima, Nishino, Ojima, Nakamura, Arima, Fukami, Okuda, Yamagishi: "Dipeptidyl peptidase-4 deficiency protects against experimental diabetic nephropathy partly by blocking the advanced glycation end products-receptor axis." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 95, Issue 5, pp. 525-33, (2015) (PubMed).

    Takikawa, Nakamura, Ishihara, Takabayashi, Fujita, Hattori, Kushibiki, Ishihara: "Improved angiogenesis and healing in crush syndrome by fibroblast growth factor-2-containing low-molecular-weight heparin (Fragmin)/protamine nanoparticles." in: The Journal of surgical research, Vol. 196, Issue 2, pp. 247-57, (2015) (PubMed).

    Nakajima, Kubo, Ihara, Hikida, Danjo, Nakatsuji, Shahani, Itakura, Ono, Azuma, Inui, Kamiya, Sawa, Takeuchi: "Nuclear-translocated Glyceraldehyde-3-phosphate Dehydrogenase Promotes Poly(ADP-ribose) Polymerase-1 Activation during Oxidative/Nitrosative Stress in Stroke." in: The Journal of biological chemistry, Vol. 290, Issue 23, pp. 14493-503, (2015) (PubMed).

    Ampem, Azegrouz, Bacsadi, Balogh, Schmidt, Thuróczy, Röszer: "Adipose tissue macrophages in non-rodent mammals: a comparative study." in: Cell and tissue research, (2015) (PubMed).

    Nakayama, Fujita, Ishihara, Ishihara, Ogata, Yamamoto, Shimizu, Maehara, Kanatani, Tachibana: "Improved survival rate by temperature control at compression sites in rat model of crush syndrome." in: The Journal of surgical research, Vol. 188, Issue 1, pp. 250-9, (2014) (PubMed).

    Chao, Chang, Su, Su: "Inducible nitric oxide synthase mediates MG132 lethality in leukemic cells through mitochondrial depolarization." in: Free radical biology & medicine, Vol. 74, pp. 175-87, (2014) (PubMed).

    Grutzmacher, Park, Zhao, Morrison, Sheibani, Sorenson: "Aberrant production of extracellular matrix proteins and dysfunction in kidney endothelial cells with a short duration of diabetes." in: American journal of physiology. Renal physiology, Vol. 304, Issue 1, pp. F19-30, (2013) (PubMed).

    Kim, Patel, Muldoon-Jacobs, Bisht, Aykin-Burns, Pennington, van der Meer, Nguyen, Savage, Owens, Vassilopoulos, Ozden, Park, Singh, Abdulkadir, Spitz, Deng, Gius: "SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress." in: Cancer cell, Vol. 17, Issue 1, pp. 41-52, (2010) (PubMed).

  • Target
    Nitrotyrosine
    Abstract
    Nitrotyrosine Produkte
    Substanzklasse
    Chemical
    Hintergrund
    Protein tyrosine nitration results in a post-translational modification that is increasingly receiving attention as an important component of nitric oxide signaling (2). While multiple nonenzymatic mechanisms are known to be capable of producing nitrated tyrosine residues, most tyrosine nitration events involve catalysis by metalloproteins such as myeloperoxidase, eosino-philperoxidase (3), myoglobin, the cytochrome P-450s, superoxide dismutase and prostacyclin synthase. Nitrotyrosine may also serve as a biomarker for the effects of reactive nitrogen oxides, based on tyrosine residues becoming nitrated in proteins at sites of inflammation induced tissue injury (1). The presence of nitro tyrosine-containing proteins therefore has shown high correlation to disease states such as atherosclerosis, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis (4).
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