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Nitrotyrosine Antikörper (APC)

AA, ELISA, FACS, ICC, IF, IHC, IP, WB Wirt: Maus Monoclonal 39B6 APC
Produktnummer ABIN2486191
$551.20
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 3 bis 4 Werktagen
  • Target Alle Nitrotyrosine Antikörper anzeigen
    Nitrotyrosine
    Reaktivität
    Bitte anfragen
    Wirt
    • 32
    • 26
    • 8
    Maus
    Klonalität
    • 34
    • 31
    Monoklonal
    Konjugat
    • 33
    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Nitrotyrosine Antikörper ist konjugiert mit APC
    Applikation
    • 50
    • 32
    • 25
    • 22
    • 21
    • 15
    • 13
    • 13
    • 12
    • 11
    • 10
    • 9
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Antibody Array (AA), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
    Spezifität
    Recognizes 3-nitrotyrosine moieties. No detectable cross-reactivity with non-nitrated tyrosine. Not species specific.
    Aufreinigung
    Protein G Purified
    Immunogen
    3-(4-hydroxy-3-nitrophenylacetamido) propionic acid-bovine serum albumin
    Klon
    39B6
    Isotyp
    IgG2a
  • Applikationshinweise
    • WB (1:1400)
    • IHC (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    0.7 μg/ml of ABIN2486191 was sufficient for detection of 5 μg SIN-1 treated BSA by Western Blot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    Nitrotyrosine
    Abstract
    Nitrotyrosine Produkte
    Substanzklasse
    Chemical
    Hintergrund
    Protein tyrosine nitration results in a post-translational modification that is increasingly receiving attention as an important component of nitric oxide signaling (2). While multiple nonenzymatic mechanisms are known to be capable of producing nitrated tyrosine residues, most tyrosine nitration events involve catalysis by metalloproteins such as myeloperoxidase, eosino-philperoxidase (3), myoglobin, the cytochrome P-450s, superoxide dismutase and prostacyclin synthase. Nitrotyrosine may also serve as a biomarker for the effects of reactive nitrogen oxides, based on tyrosine residues becoming nitrated in proteins at sites of inflammation induced tissue injury (1). The presence of nitro tyrosine-containing proteins therefore has shown high correlation to disease states such as atherosclerosis, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis (4).
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