RAGE Antikörper (Extracellular Domain)

Produktnummer ABIN360934

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch RAGE in WB, IF und IHC (fro). Er zeigt eine Reaktivität gegenüber Maus und wurde in 1 Publikation erwähnt.

Kurzübersicht für RAGE Antikörper (Extracellular Domain) (ABIN360934)

Target: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser RAGE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 2B65

Produktdetails anti-RAGE Antikörper

Bindungsspezifität: Extracellular Domain

Spezifität: This antibody detects RAGE.

Aufreinigung: Protein A/G Affinity Chromatography

Immunogen: Mouse Recombinant RAGE extracellular domain. Remarks: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from an immunized rat).

Isotyp: IgG2

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500-1/1000. Immunohistochemistry on Frozen Sections: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.

Konzentration: 0,5 mg/mL

Buffer: PBS without preservatives

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-RAGE Antikörper (ABIN360934)

Aue, Englert, Harrer, Schwiering, Gaab, König, Adams, Schmidtko, Friebe, Groneberg: "NO-sensitive guanylyl cyclase discriminates pericyte-derived interstitial from intra-alveolar myofibroblasts in murine pulmonary fibrosis." in: Respiratory research, Vol. 24, Issue 1, pp. 167, (2023) (PubMed).

Details zu RAGE

Target: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Andere Bezeichnung: RAGE / AGER

Hintergrund: The Receptor for Advanced Glycation Endproducts (RAGE) is a member of the Immunoglobin superfamily of cell surface markers. This protein is able to interact with many molecules including: advanced glycation endproducts (AGE), amphoterin, and ligands. Research has shown that the accumulation of RAGE ligands in the biological system (endothelium mononuclear phagocytes, neurons and smooth muscle cells) can lead to destructive tissue diseases such as diabetic retinopathy, amyloidoses, tumors and inflammation disorders. RAGE is expressed by endothelium mononuclear phagocytes, smooth muscle and neurons.Synonyms: Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products

Gen-ID: 10090

UniProt: Q62151

Pathways: Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteine