IL3RA Antikörper (Extracellular Domain)

Produktnummer ABIN360906

Dieses Anti-IL3RA-Antikörper ist ein Ratte Monoklonal-Antikörper zur Detektion von IL3RA in WB. Geeignet für Maus.

Kurzübersicht für IL3RA Antikörper (Extracellular Domain) (ABIN360906)

Target: IL3RA (Interleukin 3 Receptor, alpha (IL3RA))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser IL3RA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 9G52

Produktdetails anti-IL3RA Antikörper

Bindungsspezifität: Extracellular Domain

Spezifität: This antibody detects IL-3Ralpha. Do not cross react to IL-3Rbeta.

Aufreinigung: Protein A/G affinity chromatography

Immunogen: Recombinant protein of IL-3Ralpha extracellular domain.

Isotyp: IgG2

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu IL3RA

Target: IL3RA (Interleukin 3 Receptor, alpha (IL3RA))

Andere Bezeichnung: CD123 / IL3RA

Hintergrund: IL3RA (CD123) is a member of the immunoglobulin superfamily that is expressed on hematopoietic progenitors, basophils, mast cells, and megakaryocytes. This transmembrane glycoprotein can bind IL3 with low affinity but cannot transduce signals without association with additional protein partners. CD123 can complex with either common beta chain (CDw131) or the IL3RB chain to form high affinity heterodimeric IL3 receptors. CDw131 can complex with the Alpha subunits of the mouse IL3R, IL5R and GMCSFR to form high affinity receptors, while the IL3RB subunit is specific for IL3 but binds with low affinity. IL3 binding to the receptor complex can induce proliferation and differentiation of hematopoietic cells. It is present in Hematopoietic progenitors, basophils, mast cells and megakaryocytes.Synonyms: IL-3R-alpha, IL3 receptor alpha, Interleukin-3 receptor subunit alpha

Gen-ID: 16188

NCBI Accession: NP_032395

UniProt: P26952

Pathways: JAK-STAT Signalweg