DUSP6 Antikörper (Middle Region)

Produktnummer ABIN360781

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch DUSP6 in WB und EIA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für DUSP6 Antikörper (Middle Region) (ABIN360781)

Target: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DUSP6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-DUSP6 Antikörper

Bindungsspezifität: Middle Region

Spezifität: This antibody reacts to DUSP6.

Aufreinigung: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the central region of human DUSP6.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu DUSP6

Target: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Andere Bezeichnung: DUSP6

Hintergrund: DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associatedwith cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Twotranscript variants encoding different isoforms have been found for the DUSP6 gene.Synonyms: Dual specificity protein phosphatase 6, Dual specificity protein phosphatase PYST1, MKP3, Mitogen-activated protein kinase phosphatase 3, PYST1

Gen-ID: 1848, 9606

UniProt: Q16828

Pathways: Neurotrophin Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades