ACO2 Antikörper (Center)

Produktnummer ABIN357262

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ACO2 in WB und EIA. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus und wurde in 4+ Publikationen erwähnt.

Kurzübersicht für ACO2 Antikörper (Center) (ABIN357262)

Target: ACO2 (Aconitase 2, Mitochondrial (ACO2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ACO2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-ACO2 Antikörper

Bindungsspezifität: Center

Spezifität: This antibody detects ACO2 at center.

Aufreinigung: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the central region of human Aconitase.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA 1: 1,000. Western blot 1: 100 - 1: 500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-ACO2 Antikörper (ABIN357262)

Carpenter, Paw, Dewhirst, Lo: "Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells." in: Oncogene, Vol. 34, Issue 5, pp. 546-57, (2015) (PubMed).

Fernandes, Uytterhoeven, Kuenen, Wang, Slabbaert, Swerts, Kasprowicz, Aerts, Verstreken: "Reduced synaptic vesicle protein degradation at lysosomes curbs TBC1D24/sky-induced neurodegeneration." in: The Journal of cell biology, Vol. 207, Issue 4, pp. 453-62, (2014) (PubMed).

Maity, Bindu, Dey, Goyal, Alam, Pal, Mitra, Bandyopadhyay et al.: "Indomethacin, a non-steroidal anti-inflammatory drug, develops gastropathy by inducing reactive oxygen species-mediated mitochondrial pathology and associated apoptosis in gastric mucosa: a novel ..." in: The Journal of biological chemistry, Vol. 284, Issue 5, pp. 3058-68, (2009) (PubMed).

OConnell, Gannon, Doran, Ohlendieck: "Proteomic profiling reveals a severely perturbed protein expression pattern in aged skeletal muscle." in: International journal of molecular medicine, Vol. 20, Issue 2, pp. 145-53, (2007) (PubMed).

Details zu ACO2

Target: ACO2 (Aconitase 2, Mitochondrial (ACO2))

Andere Bezeichnung: ACO2

Hintergrund: ACO2 belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.Synonyms: Aconitase 2, Aconitate hydratase mitochondrial

Molekulargewicht: 85425 Da.

Gen-ID: 50, 9606

UniProt: Q99798