LBP Antikörper
(2 Referenzen)Kurzübersicht für LBP Antikörper (ABIN343173)
Target
Alle LBP Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Spezifität
- Mouse LBP. The antibody blocks LPS binding to membrane bound CD14.
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Kreuzreaktivität
- Human, Ratte (Rattus)
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Aufreinigung
- Protein G affinity column
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Immunogen
- native mouse LBP
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Isotyp
- IgG1
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anti-Lipopolysaccharide Binding Protein (LBP) (AA 226-480) antibody
LBP Reaktivität: Ratte WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Lipopolysaccharide Binding Protein (LBP) (AA 224-468) antibodyLBP Reaktivität: Rind (Kuh) WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Lipopolysaccharide Binding Protein (LBP) (AA 25-481) antibodyLBP Reaktivität: Maus WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Lipopolysaccharide Binding Protein (LBP) antibodyLBP Reaktivität: Human WB, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Lipopolysaccharide Binding Protein (LBP) antibodyLBP Reaktivität: Human IHC (p) Wirt: Maus Monoclonal biG42 unconjugated
anti-Lipopolysaccharide Binding Protein (LBP) antibodyLBP Reaktivität: Maus ELISA Wirt: Maus Monoclonal biG35 unconjugated
anti-Lipopolysaccharide Binding Protein (LBP) (AA 27-481) antibodyLBP Reaktivität: Human WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Lipopolysaccharide Binding Protein (LBP) (AA 27-481) antibodyLBP Reaktivität: Human WB, IHC, IP, ICC Wirt: Maus Monoclonal C1 unconjugated
anti-Lipopolysaccharide Binding Protein (LBP) (AA 27-481) antibodyLBP Reaktivität: Ratte WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Lipopolysaccharide Binding Protein (LBP) antibodyLBP Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
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Applikationshinweise
- ELISA ,LBP inhibition studies, Western Blot. inhibits binding of LPS to membrane bound CD14, (Inhibits LPS-binding (0.5 ug/ml) to CD14+CHO cells (2 x 106/ml) up to 1:1000, total inhibition 1:5 Binding titre at mouse LBP- ELISA: 1:50.000 Cross reacting with rat LBP
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Reconstitute with bidistilled water
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Konzentration
- 1 mg/mL
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Buffer
- PBS, pH 7.17
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Konservierungsmittel
- Without preservative
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Lagerung
- -20 °C,-80 °C
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: "Binding of bacterial peptidoglycan to CD14." in: The Journal of biological chemistry, Vol. 273, Issue 15, pp. 8680-90, (1998) (PubMed).
: "Specific binding of soluble peptidoglycan and muramyldipeptide to CD14 on human monocytes." in: Infection and immunity, Vol. 65, Issue 3, pp. 858-64, (1997) (PubMed).
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: "Binding of bacterial peptidoglycan to CD14." in: The Journal of biological chemistry, Vol. 273, Issue 15, pp. 8680-90, (1998) (PubMed).
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- LBP (Lipopolysaccharide Binding Protein (LBP))
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Andere Bezeichnung
- Lipopolysaccharide (LPS)-Binding Protein (LBP)
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Hintergrund
- Background: Natural LBP is a 58KD glycoprotein produced in liver. It binds at lipid A of LPS with high affinity (10-9M) and reduced the cellular LPS effects at CD14+ cells (IL1ß, IL6, TNFα). It acts as opsonin for GRAM negative cells, LPS, neutrophiles and granulocytes.
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Molekulargewicht
- ~58kDa
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Gen-ID
- 16803
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UniProt
- Q61805
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Pathways
- TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process
Target
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