GFAP Antikörper

Produktnummer ABIN335275

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GFAP in WB, IHC, IHC (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Human, Ratte, Maus und Zebrafisch (Danio rerio) und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für GFAP Antikörper (ABIN335275)

Target: GFAP (Glial Fibrillary Acidic Protein (GFAP))

Reaktivität: Human, Ratte, Maus, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GFAP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: K39

Produktdetails anti-GFAP Antikörper

Spezifität: Human, mouse and rat.

Aufreinigung: Antiserum

Immunogen: K39 is a rabbit polyclonal antiserum derived by immunization of a rabbit with a glial fibrillary acidic protein preparation from human spinal cord.

Anwendungsinformationen

Applikationshinweise: K39 reacts exclusively with glial fibrillary acidic protein which is present in astrocytes in the central nervous system and Schwann cells. K39 is suitable for immunoblotting and immunohistochemistry on frozen and paraffin-embedded tissues. Optimal antibody dilution should be determined by titration, recommended range is 1:100 - 1:200 for immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and 1:100 - 1:1000 for immunoblotting applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: 4 °C

Referenzen für anti-GFAP Antikörper (ABIN335275)

Herpers, Ramaekers, Aldeweireldt, Moesker, Slooff: "Co-expression of glial fibrillary acidic protein- and vimentin-type intermediate filaments in human astrocytomas." in: Acta neuropathologica, Vol. 70, Issue 3-4, pp. 333-9, (1986) (PubMed).

Ramaekers, Puts, Moesker, Kant, Huysmans, Haag, Jap, Herman, Vooijs: "Antibodies to intermediate filament proteins in the immunohistochemical identification of human tumours: an overview." in: The Histochemical journal, Vol. 15, Issue 7, pp. 691-713, (1983) (PubMed).

Details zu GFAP

Target: GFAP (Glial Fibrillary Acidic Protein (GFAP))

Andere Bezeichnung: Glial fibrillary acidic protein / GFAP

Hintergrund: GFAP (55 kD) is selectively located in astrocytes and represents the major constituent of astrocytic intermediate filaments. GFAP expression levels are highly variable during development of the central nervous system. In adults, GFAP levels increase as a result of the proliferation of astrocytes that occurs in a response to a variety of physical, chemical and etiological insults, including Alzheimer€™s disease, epilepsy and multiple sclerosis. In the peripheral nervous system GFAP is expressed by Schwann cells. Upon differentiation, myelin forming Schwann cells down-regulate GFAP, whereas in non-myelin forming Schwann cells GFAP persists into adulthood.