Integrin Alpha2b Antikörper

Produktnummer ABIN320116

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch Integrin Alpha2b in FACS, IP und IHC (fro). Er zeigt eine Reaktivität gegenüber Maus und wurde in 6+ Publikationen erwähnt.

Kurzübersicht für Integrin Alpha2b Antikörper (ABIN320116)

Target: Integrin Alpha2b (CD41)

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser Integrin Alpha2b Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: MWReg30

Produktdetails anti-Integrin Alpha2b Antikörper

Spezifität: This antibody recognizes the integrin alpha IIb subunit CD41. Clone MWReg30 has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo (Nieswandt et al., 1999). SM2035A is recommended for use in functional studies.

Aufreinigung: Affinity Chromatography on Protein G.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow Cytometry (1/50-1/100): Use 10 μL to label 10^6 cells in 100 μL. Immunohistology on Frozen Sections. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, containing 0.09 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Referenzen für anti-Integrin Alpha2b Antikörper (ABIN320116)

Koski, Bramante, Kipar, Oksanen, Juhila, Vassilev, Joensuu, Kanerva, Hemminki: "Biodistribution Analysis of Oncolytic Adenoviruses in Patient Autopsy Samples Reveals Vascular Transduction of Noninjected Tumors and Tissues." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 23, Issue 10, pp. 1641-52, (2016) (PubMed).

Pennings, Siljee, Imholz, Kuc, de Vries, Schielen, Rodenburg: "Comparison of different blood collection, sample matrix, and immunoassay methods in a prenatal screening setting." in: Disease markers, Vol. 2014, pp. 509821, (2015) (PubMed).

Teeling, Carare, Glennie, Perry: "Intracerebral immune complex formation induces inflammation in the brain that depends on Fc receptor interaction." in: Acta neuropathologica, Vol. 124, Issue 4, pp. 479-90, (2012) (PubMed).

Haglund, Tillgren, Addis, Wenglén, Recklies, Heinegård: "Identification and characterization of the integrin alpha2beta1 binding motif in chondroadherin mediating cell attachment." in: The Journal of biological chemistry, Vol. 286, Issue 5, pp. 3925-34, (2011) (PubMed).

Sullivan, Wang, Tawfik, Luyendyk: "Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 115, Issue 1, pp. 286-94, (2010) (PubMed).

Leung, Greene, Ni, Raymond, Lehnert, Langley, Krissansen: "Cloning of the mucosal addressin MAdCAM-1 from human brain: identification of novel alternatively spliced transcripts." in: Immunology and cell biology, Vol. 74, Issue 6, pp. 490-6, (1997) (PubMed).

Details zu Integrin Alpha2b

Target: Integrin Alpha2b (CD41)

Andere Bezeichnung: CD41 / ITGA2B

Hintergrund: CD41, a ~125 kDa single pass type 1 transmembrane glycoprotein, is expressed on platelets, megakaryocytes, mast cells and hematopoietic progenitors and forms a heterodimer with CD61. CD41/CD61 is important for platelet adhesion and aggregation.Synonyms: GP2B, GPalpha IIb, ITGAB, Integrin alpha-IIb, Platelet membrane glycoprotein IIb

Gen-ID: 16399

NCBI Accession: NP_034705

UniProt: Q9QUM0

Pathways: Integrin Complex