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c-MYC Antikörper (pSer62)

Name: c-MYC Antikörper (pSer62)
SKU: ABIN3201011
Price: 883.08 EUR
Availability: InStock

MYC Reaktivität: Human WB, IF Wirt: Maus Monoclonal 33A12E10 unconjugated

Western Blotting (WB) image for anti-Myc Proto-Oncogene protein (MYC) (pSer62) antibody (ABIN3201011) (c-MYC Antikörper (pSer62))

Immunofluorescence (IF) image for anti-Myc Proto-Oncogene protein (MYC) (pSer62) antibody (ABIN3201011) (c-MYC Antikörper (pSer62))

2 Abbildungen

(2 Referenzen)

Produktnummer ABIN3201011

Datenblatt (PDF)

Target Alle c-MYC (MYC) Antikörper anzeigen

c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))
Bindungsspezifität
59

48

43

41

24

22

17

15

15

13

10

7

7

6

6

4

4

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer62
Reaktivität
359

162

114

15

15

13

13

13

9

9

9

6

6

6

5

4

3

3

2

2

1

1

1

1

1

1

1
Human
Wirt
277

100

7

5

3

1

1
Maus
Passende Sekundärantikörper
Klonalität
272

121
Monoklonal
Konjugat
192

31

24

23

8

8

5

5

5

5

5

5

5

5

5

5

5

5

5

5

5

5

5

3

2

2

2

2

2

2

2

1

1

1

1

1

1
Dieser c-MYC Antikörper ist unkonjugiert
Applikation
287

140

97

82

74

58

55

28

26

24

18

14

12

11

7

4

2

1

1

1

1
Western Blotting (WB), Immunofluorescence (IF)

Kreuzreaktivität (Details)

Expected to react with mouse, rat from the sequence identity.

Aufreinigung

Purified

Immunogen

Synthetic peptide containing pSer62 of cMyc

Klon

33A12E10

Isotyp

IgG2b kappa

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Applikationshinweise

1. Western blotting: ~1 g/mL

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

1 mg/mL

Buffer

PBS, 50 % glycerol

Konservierungsmittel

Azide free

Lagerung

-20 °C
Khanna, Böckelman, Hemmes, Junttila, Wiksten, Lundin, Junnila, Murphy, Evan, Haglund, Westermarck, Ristimäki: "MYC-dependent regulation and prognostic role of CIP2A in gastric cancer." in: Journal of the National Cancer Institute, Vol. 101, Issue 11, pp. 793-805, (2009) (PubMed).

Junttila, Puustinen, Niemelä, Ahola, Arnold, Böttzauw, Ala-aho, Nielsen, Ivaska, Taya, Lu, Lin, Chan, Wang, Grènman, Kast, Kallunki, Sears, Kähäri, Westermarck: "CIP2A inhibits PP2A in human malignancies." in: Cell, Vol. 130, Issue 1, pp. 51-62, (2007) (PubMed).
Target

c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Andere Bezeichnung

C-Myc (MYC Produkte)

Hintergrund

CMyc is a proto-oncogene, which is overexpressed in a wide range of human cancers. Myc gene encodes a transcription factor that regulates a great number of genes through binding on Enhancer Box sequences (E-boxes) and recruiting histone acetyltransferase. It can also act as a transcriptional repressor. It regulates cell growth, apoptosis, differentiation and stem cell self-renewal. Previous studies on the phosphorylation of c-Myc have suggested functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK), cell proliferation and cell cycle regulation. Phosphorylation at Ser62 is required for Ras-induced stabilization and is prerequisite for phosphorylation at Thr58 for its degradation.

UniProt

P01106

Pathways

p53 Signalweg, Zellzyklus, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effekt