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ASK1 Antikörper (C-Term)
MAP3K5
Reaktivität: Human
WB, IF, IHC (fro)
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-ASK1 Antikörper
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Target
Alle ASK1 (MAP3K5) Antikörper anzeigen
ASK1 (MAP3K5)
(Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5))
Bindungsspezifität
Alle Epitope für ASK1 Antikörper
C-Term
Reaktivität
Alle Reaktivitäten für ASK1 Antikörper
Human
Wirt
Alle Wirte für ASK1 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für ASK1 Antikörper
Polyklonal
Konjugat
Alle Konjugate für ASK1 Antikörper
Dieser ASK1 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für ASK1 Antikörper
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
Spezifität
This antibody recognises ASK1 (Apoptosis signal-regulating kinase 1) a 155 kDa protein belonging to the protein kinase superfamily.
Aufreinigung
Purified
Immunogen
A peptide corresponding to amino acids near the carboxy terminus of human ASK1.
Isotyp
IgG
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Anwendungsinformationen
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Applikationshinweise
Immunohistochemistry on frozen sections: 10g/mL. Western Blot: 0.5 - 1.0g/mL, detects a band of approximately 155 kDa in SW1353 celllysates. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
0.5 mg/mL
Buffer
Phosphate buffered saline containing 0.02 % Sodium Azide (NaN3)
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Details zu ASK1
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Target
ASK1 (MAP3K5)
(Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5))
Andere Bezeichnung
MEKK5 / ASK1 (MAP3K5 Produkte )
Synonyme
ASK1 antikoerper, MAPKKK5 antikoerper, MEKK5 antikoerper, mitogen-activated protein kinase kinase kinase 5 antikoerper, MUD21.11 antikoerper, MUD21_11 antikoerper, 7420452D20Rik antikoerper, ASK antikoerper, Mekk5 antikoerper, Ask1 antikoerper, RGD1306565 antikoerper, mitogen-activated protein kinase kinase kinase 5 antikoerper, MAP3K5 antikoerper, MAPKKK5 antikoerper, Map3k5 antikoerper, map3k5 antikoerper
Hintergrund
ASK1 is a serine/threonine kinase, also known as MAP kinase kinase kinase (MAPKKK), and plays an important role in the apoptotic response to various stimuli including oxidative stress, cytokines (e.g. TNF) and endoplasmic reticulum stress. Akt in conjunction to Hsp90 phosphorylates ASK1 at Ser83 to inhibit ASK1 induced apoptosis. ASK1 is widely expressed in a variety of human tissues including the heart and pancreas.Synonyms: Apoptosis signal-regulating kinase 1, MAP3K5, MAPK/ERK kinase kinase 5, MAPKKK5, Mitogen-activated protein kinase kinase kinase 5
Gen-ID
4217
NCBI Accession
NP_005914
UniProt
Q99683
Pathways
MAPK Signalweg , Positive Regulation of Endopeptidase Activity , Unfolded Protein Response
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