DLL4 Antikörper (Internal Region)

Produktnummer ABIN318838

Produktdetails anti-DLL4 Antikörper

Target: DLL4 (delta-Like 4 (DLL4))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DLL4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects human Delta-like ligand 4 (DLL4), also known as Delta-4.

Aufreinigung: Purified

Immunogen: Synthetic peptide corresponding to the internal region of human DLL4.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on paraffin sections: 5 - 15g/mL. ELISA: 1: 3000 - 1: 15000. Western Blot: 1: 300 - 1: 1500, detects a band of approximately 74 kDa in pancreatic celllysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0mg/mL

Buffer: Phosphate buffered saline pH 7.2 containing 0.09 % Sodium Azide (NaN3)

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-DLL4 Antikörper (ABIN318838)

Wang, Lu, Zhang, Du, Tang, Wang, Lu, Hu: "GEN-27, a Newly Synthetic Isoflavonoid, Inhibits the Proliferation of Colon Cancer Cells in Inflammation Microenvironment by Suppressing NF-κB Pathway." in: Mediators of inflammation, Vol. 2016, pp. 2853040, (2017) (PubMed).

Li, Yan, Wang, Jing, Li, Liu, Yu, Fan: "Effects of canonical NF-κB signaling pathway on the proliferation and odonto/osteogenic differentiation of human stem cells from apical papilla." in: BioMed research international, Vol. 2014, pp. 319651, (2014) (PubMed).

Villaamil, Gallego, Valladares-Ayerbes, Caínzos, Aparicio: "Multiple biomarker tissue arrays: A computational approach to identifying protein-protein interactions in the EGFR/ERK signalling pathway." in: Journal of molecular signaling, Vol. 7, Issue 1, pp. 14, (2012) (PubMed).

González-Mariscal, Garay, Quirós: "Identification of claudins by western blot and immunofluorescence in different cell lines and tissues." in: Methods in molecular biology (Clifton, N.J.), Vol. 762, pp. 213-31, (2011) (PubMed).

Details zu DLL4

Target: DLL4 (delta-Like 4 (DLL4))

Andere Bezeichnung: delta-Like Protein 4 / DLL4 (DLL4 Produkte)

Synonyme: hdelta2 antikoerper, Delta4 antikoerper, si:ch211-244p18.5 antikoerper, zgc:136596 antikoerper, delta like canonical Notch ligand 4 antikoerper, delta-like 4 (Drosophila) antikoerper, DLL4 antikoerper, Dll4 antikoerper, dll4 antikoerper

Hintergrund: DLL4 is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the Notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumour vessels of clear-cell renal tumours and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumour growth, with no apparent toxicity.Synonyms: Delta 4, Drosophila Delta homolog 4

Gen-ID: 54567

NCBI Accession: NP_061947

UniProt: Q9NR61

Pathways: Notch Signalweg