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BMI1 Antikörper (Middle Region)

BMI1 Reaktivität: Human, Maus, Ratte WB, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN318769
  • Target Alle BMI1 Antikörper anzeigen
    BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))
    Bindungsspezifität
    • 9
    • 8
    • 7
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    • 103
    • 45
    • 26
    • 10
    • 8
    • 7
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 73
    • 28
    • 6
    Kaninchen
    Klonalität
    • 76
    • 31
    Polyklonal
    Konjugat
    • 76
    • 8
    • 7
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BMI1 Antikörper ist unkonjugiert
    Applikation
    • 83
    • 43
    • 38
    • 19
    • 12
    • 12
    • 11
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Spezifität
    This antibody recognises 37 kDa polycomb complex protein BMI-1, involved in segment specification, cell growth and maintenance, transcriptional regulation and chromatin modification.
    Aufreinigung
    Purified
    Immunogen
    15 amino acid peptide sequence near the centre of human BMI-1.
    Isotyp
    IgG
    Top Product
    Discover our top product BMI1 Primärantikörper
  • Applikationshinweise
    Western Blot: 0.5 - 1.0g/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline containing 0.02 % Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))
    Andere Bezeichnung
    BMI-1 / RNF51 (BMI1 Produkte)
    Hintergrund
    BMI-1 is a proto-oncogene which cooperates with the myc oncogene to produce B-lymphomas. It is required in the regulation of normal adult and leukaemic stem cells, making BMI-1 a potential target for stem cell proliferation and anti-cancer therapies. BMI-1 represses transcription at the ink4 locus which contains tumour suppressors p16 and p19Arf. BMI-1 is a component of the Polycomb group (PcG) multiprotein PRC1 complex which ubiquitinates histone-2A at lys119, resulting in a heritable change in the ability of chromatin to express genes. BMI-1 is also required to stimulate the E3 ubiquitin ligase activity of RNF2/RING2 within the PRC1 complex.Synonyms: BMI1, PCGF4, Polycomb group RING finger protein 4, RING finger protein 51
    Gen-ID
    100532731
    NCBI Accession
    NP_001190991
    UniProt
    P35226
    Pathways
    Zellzyklus, Autophagie
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