CD44 Antikörper

Produktnummer ABIN317946

Dieses Anti-CD44-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CD44 in WB. Geeignet für Human, Maus und Ratte.

Kurzübersicht für CD44 Antikörper (ABIN317946)

Target: CD44

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD44 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CD44 Antikörper

Spezifität: This antibody detects endogenous levels of CD44 protein.(region surrounding Glu702)

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CD44

Target: CD44

Andere Bezeichnung: CD44

Hintergrund: Cell adhesion molecules (CAMs) are a family of closely related cell surface glycoproteins involved in cell-cell interactions during growth and play an important role in embryogenesis and development. HCAM (also designated CD44) is a member of the CAM family and participates in the progression of IgA nephropathy by binding hyaluronic acid and osteopontin. The colocalization of osteopontin in the bladder epithelium with αVβ3 integrin and HCAM suggests a role for HCAM in maintaining the integrity of the transitional epithelium by providing the sealing and adhesiveness needed for the impermeable state of the bladder. HCAM is closely related to the secretory phase of the normal menstrual cycle and its expression is decreased in hyperplasia and in cancer cases. Decreased HCAM expression may be functionally involved in the multiple mechanisms of the development and progression of endometrial lesions.Synonyms: CDw44, ECMR-III, Epican, Extracellular matrix receptor III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, LHR, MDU2, MDU3, MIC4, PGP-1, Phagocytic glycoprotein 1

Molekulargewicht: approx. 90 kDa

Gen-ID: 960

NCBI Accession: NP_000601

UniProt: P16070

Pathways: Glycosaminoglycan Metabolic Process, Autophagie, Negative Regulation of intrinsic apoptotic Signaling