MMP3 Antikörper (C-Term)

Produktnummer ABIN307118

Der Maus Monoklonal anti-MMP3 Antikörper wird verwendet zum Nachweis von MMP3 in Proben von Human. Er wurde validiert für WB, IHC und ELISA.

Kurzübersicht für MMP3 Antikörper (C-Term) (ABIN307118)

Target: MMP3 (Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MMP3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Klon: 1B4

Produktdetails anti-MMP3 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Mouse anti Human Matrix Metalloproteinase 3 (MMP3)

Kreuzreaktivität: Human

Produktmerkmale: The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including Collagen, gelatin, Fibronectin, Laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also designated stromelysin-1, 2 and 3, respectively) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.

Aufreinigung: Protein A/G Chromatography

Immunogen: Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with a synthetic peptide derived from the C-terminus of the human MMP3 protein and mouse myeloma Ag8563 cells.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Antibody can be used for Western blotting (1-2 μg/mL) and immunohistochemistry on formlin-fixed paraffin-embedded tissue sections (1-5 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu MMP3

Target: MMP3 (Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3))

Andere Bezeichnung: Matrix Metalloproteinase 3 (MMP3)

Hintergrund: SL-1, Matrix metalloproteinase-3, MMP-3, Transin-1

UniProt: P08254