Nitrotyrosine Antikörper

Produktnummer ABIN306957

Der Maus Monoklonal anti-Nitrotyrosine Antikörper (Klon 2A12) (ABIN306957) detektiert spezifisch Nitrotyrosine in WB.

Kurzübersicht für Nitrotyrosine Antikörper (ABIN306957)

Target: Nitrotyrosine

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Nitrotyrosine Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 2A12

Produktdetails anti-Nitrotyrosine Antikörper

Verwendungszweck: Mouse anti Nitrotyrosine

Spezifität: Nitrotyrosine

Produktmerkmale: Protein tyrosine nitration results in a post-translational modification that is increasingly receiving attention as an important component of nitric oxide signaling. While multiple nonenzymatic mechanisms are known to be capable of producing nitrated tyrosine residues, most tyrosine nitration events involve catalysis by metalloproteins such as myeloperoxidase, eosinophilperoxidase, myoglobin, the cytochrome P-450s, superoxide dismutase and prostacyclin synthase. Various studies have shown that protein tyrosinenitration is limited to specific proteins and that the process is selective. For example, exposure of human surfactant protein A (SP-A) to oxygen-nitrogen intermediates generated by activated alveolar macrophages resulted in specific nitration of SP-A at tyrosines 164 and 166, while addition of 1.2 mMCO 2 resulted in additional nitration at tyrosine 161. The presence of nitrotyrosine-containing proteins has shown high correlation to disease states such as atherosclerosis, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis.

Immunogen: 3-Nitrotyrosine-KLH

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Antibody can be used for Western blotting (Suggested dilution - 1:1000) and immunohistochemistry. Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu Nitrotyrosine

Target: Nitrotyrosine

Substanzklasse: Chemical