Adiponectin Receptor 1 Antikörper (N-Term)

Produktnummer ABIN306945

Dieses Anti-Adiponectin Receptor 1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Adiponectin Receptor 1 in WB. Geeignet für Human.

Kurzübersicht für Adiponectin Receptor 1 Antikörper (N-Term) (ABIN306945)

Target: Adiponectin Receptor 1 (ADIPOR1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Adiponectin Receptor 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Adiponectin Receptor 1 Antikörper

Bindungsspezifität: N-Term

Kreuzreaktivität: Human

Produktmerkmale: Adiponectin receptor protein 1, Progestin and adipoQ receptor family member I, ADIPOR1, PAQR1,CGI-45,Alzheimer's disease (AD) is characterized by formation of plaques of amyloid beta peptide (Abeta). Autosomally-inherited AD had been shown only in connection with coding sequence mutations. Likely transcription factors whose mutation can cause loss of function are ADR1, MIG1, and PuF, and for gain of function, E12/E47, ITF-2, and RFX2. Adr1 controls the expression of genes required for ethanol, glycerol, and fatty acid utilization (in yeast). Adr1 can act directly on the promoters of ADH2, ACS1, GUT1, CTA1, and POT1. The yeast homolog of the AMP-activated protein kinase, Snf1, promotes Adr1 chromatin binding in the absence of glucose, and the protein phosphatase complex, Glc7.Reg1, represses its binding in the presence of glucose. A post-translational process is invloved in the regulation of Adr1 binding. Chromatin binding by Adr1 is not the only step in ADH2 transcription that is regulated by glucose repression, Adr1 can bind to chromatin in repressed conditions in the presence of hyperacetylated histones. In yeast, nuclear extracts prepared from glucose-repressed and glucose-derepressed cells are equally capable of supporting miniAdr1-dependent transcription and pre-initiation complex formation.

Aufreinigung: Ammonium Sulfate Precipitation

Immunogen: Synthetic peptide near the N terminus of human Adiponectin Receptor 1 protein.

Anwendungsinformationen

Applikationshinweise: Antibody can be used for Western blotting (5-10 μg/mL) and ELISA. Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu Adiponectin Receptor 1

Target: Adiponectin Receptor 1 (ADIPOR1)

Andere Bezeichnung: Adiponectin Receptor 1

UniProt: Q96A54

Pathways: AMPK Signaling