TYROBP Antikörper (Cytoplasmic Domain)

Produktnummer ABIN306916

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TYROBP in WB und IP. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für TYROBP Antikörper (Cytoplasmic Domain) (ABIN306916)

Target: TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TYROBP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-TYROBP Antikörper

Bindungsspezifität: Cytoplasmic Domain

Kreuzreaktivität: Human, Maus

Produktmerkmale: TYRO protein tyrosine kinase-binding protein, DNAX-activation protein 12, Killer-activating receptor-associated protein, KARAP, TYROBP,DAP12 is a transmembrane adaptor protein that is non-covalently associated with several cell surface receptors on natural killer (NK), myeloid, and presumably neuronal cells (1,2). DAP12 contains an ITAM domain that preferentially recruits the protein tyrosine kinase Syk to initiate signal transduction (3). Deficiency of DAP12 results in reduced antigen presentation function by myeloid cells and defects in function of certain NK cell receptors in mice (4,5), as well as presenile dementia and bone cysts in humans (6).

Aufreinigung: Ammonium Sulfate Precipitation

Immunogen: Rabbit immunized with recombinant DAP12 protein (cytoplasmic domain).

Anwendungsinformationen

Applikationshinweise: Antibody can be used for immunoprecipitation (2-4 μg/mg of protein lysate). Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu TYROBP

Target: TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))

Andere Bezeichnung: DAP12

UniProt: O43914