TARDBP Antikörper (AA 1-260)

Produktnummer ABIN306465

Dieses Anti-TARDBP-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von TARDBP in WB, IHC, ELISA und FACS. Geeignet für Human.

Kurzübersicht für TARDBP Antikörper (AA 1-260) (ABIN306465)

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TARDBP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Klon: K1B8

Produktdetails anti-TARDBP Antikörper

Bindungsspezifität: AA 1-260

Aufreinigung: The antibody was purified from mouse ascitic fluids by protein-G affinity chromatography

Immunogen: Recombinant human TARDBP (1-260aa) purified from E. coli

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Recommended dilution 1:1000(W.B), Recommended dilution 1:100(IHC)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: In Phosphate-Buffered Saline (pH7.4) with 0.1% Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Details zu TARDBP

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Andere Bezeichnung: TDP-43/TARDBP

Hintergrund: TAR DNA binding protein (TARDBP), also known as TDP-43, is a cellular protein. TARDBP was identified as the disease accumulating protein in patients with frontotemporal lobar degeneration (FTLD) with ubiquitin inclusions (FTLD-U) and in amyotrophic lateral sclerosis (ALS). TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. In addition, this protein regulates alternate splicing of the cystic fibrosis transmembrane receptor (CFTR) gene.

NCBI Accession: NP_031401

Pathways: Positive Regulation of Peptide Hormone Secretion