POU2AF1 Antikörper (C-Term)

Produktnummer ABIN3044424

Der Kaninchen Polyklonal anti-POU2AF1 Antikörper (ABIN3044424) detektiert spezifisch POU2AF1 in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Ratte und Maus.

Kurzübersicht für POU2AF1 Antikörper (C-Term) (ABIN3044424)

Target: POU2AF1 (POU Class 2 Associating Factor 1 (POU2AF1))

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POU2AF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-POU2AF1 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Anti-BOB1/POU2AF1 Antibody

Sequenz: EEEESNTYEL NHTLSVEGF

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: different from the related rat sequence by one amino acid,and from human sequence by four amino acids.

Produktmerkmale: Anti-BOB1/POU2AF1 Antibody. Tested in IHC, WB applications. This antibody reacts with Mouse, Rat.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of mouse BOB1, different from the related rat sequence by one amino acid, and from human sequence by four amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Rat, MouseWestern blot, 0.1-0.5 μg/mL, Mouse

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu POU2AF1

Target: POU2AF1 (POU Class 2 Associating Factor 1 (POU2AF1))

Andere Bezeichnung: POU2AF1

Hintergrund:

Background: POU2AF1 (POU domain class 2-associating factor 1), also known as OBF1, BOB1 and OCAB, is a protein that in humans is encoded by the POU2AF1 gene. POU domain proteins contain a bipartite DNA-binding domain divided by a flexible linker that enables them to adopt various monomer configurations on DNA. The versatility of POU protein operation is additionally conferred at the dimerization level. Casellas et al. (2002) reported that OCAB is essential for V (D)J recombination of a subset of Ig-kappa genes. They showed that OCAB modulates recombination by ly enhancing Ig-kappa gene transcription in vivo. Siegel et al. (2006) suggested that, together with dysregulation of other OCAB target genes, altered regulation of SYK may help explain the magnitude of defects observed in B-cell development, including the pre-B1-to-pre-B2 transition, and immune responses in Ocab -/- mice.

Gene Full Name: POU domain, class 2, associating factor 1

Molekulargewicht: 37 kDa

Gen-ID: 18985

UniProt: Q64693