Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

CD40 Ligand Antikörper (N-Term)

Dieses Anti-CD40 Ligand-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CD40 Ligand in WB und IHC. Geeignet für Human und Ratte. Dieses Primary Antibody wurde in 1 Publikation zitiert.
Produktnummer ABIN3044319

Kurzübersicht für CD40 Ligand Antikörper (N-Term) (ABIN3044319)

Target

Alle CD40 Ligand (CD40LG) Antikörper anzeigen
CD40 Ligand (CD40LG)

Reaktivität

  • 196
  • 89
  • 41
  • 12
  • 10
  • 9
  • 6
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Human, Ratte

Wirt

  • 121
  • 111
  • 28
  • 11
  • 9
  • 2
  • 1
Kaninchen

Klonalität

  • 167
  • 111
  • 4
Polyklonal

Konjugat

  • 152
  • 27
  • 26
  • 14
  • 9
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CD40 Ligand Antikörper ist unkonjugiert

Applikation

  • 146
  • 141
  • 116
  • 75
  • 67
  • 54
  • 43
  • 22
  • 20
  • 15
  • 13
  • 13
  • 13
  • 7
  • 6
  • 5
  • 4
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 27
    • 16
    • 10
    • 9
    • 8
    • 8
    • 7
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 47-65, N-Term

    Verwendungszweck

    Anti-CD40L/CD40LG Antibody Picoband®

    Sequenz

    HRRLDKIEDE RNLHEDFVF

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-CD40L/CD40LG Antibody (ABIN3044319). Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the N-terminus of human CD40L, different from the related mouse sequence by three amino acids, rat sequence by four amino acids.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Human
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat
    1. Allen,R.C.,Armitage,R.J.,Conley,M.E.,Rosenblatt,H.,Jenkins,N.A.,Copeland,N.G.,Bedell, M.A.,Edelhoff,S.,Disteche,C.M.,Simoneaux,D.K.,Fanslow,W.C.,Belmont,J.,Spriggs,M.K.:CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. Science 259: 990-993, 1993. 2. Cipollone,F.,Ferri,C.,Desideri,G.,Paloscia,L.,Materazzo,G.,Mascellanti,M.,Fazia,M., Iezzi,A.,Cuccurullo,C.,Pini,B.,Bucci,M.,Santucci,A.,Cuccurullo,F.,Mezzetti,A.:Preprocedural level of soluble CD40L is predictive of enhanced inflammatory response and restenosis after coronary angioplasty. Circulation 108: 2776-2782, 2003.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

    Konservierungsmittel

    Thimerosal (Merthiolate), Sodium azide

    Vorsichtsmaßnahmen

    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Yang, Fang, Liu, Zhang, Shi, Ji, Lin, Lin: "Protective effects of chinese traditional medicine buyang huanwu decoction on myocardial injury." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2011, pp. 930324, (2012) (PubMed).

  • Target

    CD40 Ligand (CD40LG)

    Andere Bezeichnung

    CD40LG

    Hintergrund

    Synonyms: CD40 ligand,CD40-L,T-cell antigen Gp39,TNF-related activation protein,TRAP,Tumor necrosis factor ligand superfamily member 5,CD154,CD40 ligand, membrane form,CD40 ligand, soluble form,CD40LG,CD40L, TNFSF5, TRAP,

    Tissue Specificity: Specifically expressed on activated CD4+ T- lymphocytes.

    Background: CD40 ligand (CD40L) is a type II membrane protein of 261 amino acids on activated T cells that induces B cell proliferation and immunoglobulin secretion. It has homology with tumour necrosis factor-alpha and -beta, and has important functions in B-cell activation and differentiation. Human CD40L with 5 exons, is mapped to the proximal region of the mouse X chromosome on Xq26.3-27.1, and can be detected on T cells but is absent from B cells and monocytes. Since CD40L is expressed on platelets and released from them on activation, its predictive value as a marker for clinical outcome and the therapeutic effect of inhibition of glycoprotein IIb /IIIa receptor in patients with acute coronary syndromes was investigated. The soluble CD40L may be involved in the process of restenosis and that it exerts its effect by triggering a complex group of inflammatory reactions on endothelial and mononuclear cells. CD40L plays a central role in the pathophysiology of acute coronary syndromes, and has a role in the pathogenesis of coronary artery lesions.

    Sequence Similarities: Belongs to the tumor necrosis factor family.

    Molekulargewicht

    29 kDa

    UniProt

    P29965

    Pathways

    NF-kappaB Signalweg, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
Sie sind hier:
Chat with us!