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TLR7 Antikörper (C-Term)

TLR7 Reaktivität: Human, Maus, Ratte WB, IHC, FACS, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3043948
  • Target Alle TLR7 Antikörper anzeigen
    TLR7 (Toll-Like Receptor 7 (TLR7))
    Bindungsspezifität
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1020-1047, C-Term
    Reaktivität
    • 82
    • 38
    • 8
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 79
    • 17
    Kaninchen
    Klonalität
    • 68
    • 27
    • 1
    Polyklonal
    Konjugat
    • 53
    • 7
    • 7
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    Dieser TLR7 Antikörper ist unkonjugiert
    Applikation
    • 51
    • 44
    • 24
    • 16
    • 13
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)
    Verwendungszweck
    Anti-TLR7 Antibody Picoband®
    Sequenz
    QAHPYFWQCL KNALATDNHV AYSQVFKE
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins
    Produktmerkmale
    Anti-TLR7 Antibody Picoband® (ABIN3043948). Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human TLR7, different from the related mouse sequence by two amino acids.
    Isotyp
    IgG
  • Applikationshinweise
    Western blot, 0.1-0.5 μg/mL, Human
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Human, -
    Immunocytochemistry , 0.5-1 μg/mL, Human, -
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    1. Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., Reis e Sousa, C.Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.Science 303: 1529-1531, 2004. 2. Hayashi, T., Gray, C. S., Chan, M., Tawatao, R., Ronacher, L., McGargill, M. A., Datta, S. K., Carson, D. A., Corr, M.Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7. 3. Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T., Tomizawa, H., Takeda, K., Akira, S.Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.Nature Immun. 3: 196-200, 2002.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P), IHC(F) and ICC.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Esancy, Condon, Feng, Kimball, Curtright, Dhaka: "A zebrafish and mouse model for selective pruritus via direct activation of TRPA1." in: eLife, Vol. 7, (2018) (PubMed).

  • Target
    TLR7 (Toll-Like Receptor 7 (TLR7))
    Andere Bezeichnung
    TLR7 (TLR7 Produkte)
    Hintergrund

    Synonyms: Toll-like receptor 7,TLR7,UNQ248/PRO285,

    Tissue Specificity: Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.

    Background: TLR7 (Toll-like receptor 7) is protein that in humans is encoded by the TLR7 gene. Orthologs are found in mammals and birds. TLR7 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on human chromosome X. TLR7 recognises single stranded RNA in endosomes, which is a common feature of viral genomes which are internalised by macrophages.

    Sequence Similarities: Belongs to the Toll-like receptor family.

    Molekulargewicht
    121 kDa
    Gen-ID
    51284
    Pathways
    TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades
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