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TLR7 Antikörper (C-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TLR7 in WB, IHC, FACS und ICC. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte und wurde in 1 Publikation erwähnt.
Produktnummer ABIN3043948

Kurzübersicht für TLR7 Antikörper (C-Term) (ABIN3043948)

Target

Alle TLR7 Antikörper anzeigen
TLR7 (Toll-Like Receptor 7 (TLR7))

Reaktivität

  • 95
  • 44
  • 8
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 92
  • 20
Kaninchen

Klonalität

  • 80
  • 31
  • 1
Polyklonal

Konjugat

  • 67
  • 8
  • 7
  • 6
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 1
Dieser TLR7 Antikörper ist unkonjugiert

Applikation

  • 64
  • 49
  • 32
  • 17
  • 14
  • 10
  • 8
  • 7
  • 4
  • 3
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)
  • Bindungsspezifität

    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1020-1047, C-Term

    Verwendungszweck

    Anti-TLR7 Antibody Picoband®

    Sequenz

    QAHPYFWQCL KNALATDNHV AYSQVFKE

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-TLR7 Antibody Picoband® (ABIN3043948). Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the C-terminus of human TLR7, different from the related mouse sequence by two amino acids.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Human
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Human, -
    Immunocytochemistry , 0.5-1 μg/mL, Human, -
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    1. Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., Reis e Sousa, C.Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.Science 303: 1529-1531, 2004. 2. Hayashi, T., Gray, C. S., Chan, M., Tawatao, R., Ronacher, L., McGargill, M. A., Datta, S. K., Carson, D. A., Corr, M.Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7. 3. Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T., Tomizawa, H., Takeda, K., Akira, S.Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.Nature Immun. 3: 196-200, 2002.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P), IHC(F) and ICC.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Esancy, Condon, Feng, Kimball, Curtright, Dhaka: "A zebrafish and mouse model for selective pruritus via direct activation of TRPA1." in: eLife, Vol. 7, (2018) (PubMed).

  • Target

    TLR7 (Toll-Like Receptor 7 (TLR7))

    Andere Bezeichnung

    TLR7

    Hintergrund

    Synonyms: Toll-like receptor 7,TLR7,UNQ248/PRO285,

    Tissue Specificity: Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.

    Background: TLR7 (Toll-like receptor 7) is protein that in humans is encoded by the TLR7 gene. Orthologs are found in mammals and birds. TLR7 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on human chromosome X. TLR7 recognises single stranded RNA in endosomes, which is a common feature of viral genomes which are internalised by macrophages.

    Sequence Similarities: Belongs to the Toll-like receptor family.

    Molekulargewicht

    121 kDa

    Gen-ID

    51284

    Pathways

    TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades
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