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IKZF1 Antikörper (C-Term)

IKZF1 Reaktivität: Human, Maus, Ratte WB, IHC, FACS, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3043860
  • Target Alle IKZF1 Antikörper anzeigen
    IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))
    Bindungsspezifität
    • 14
    • 11
    • 8
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 428-459, C-Term
    Reaktivität
    • 51
    • 38
    • 14
    • 5
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 51
    • 16
    • 2
    Kaninchen
    Klonalität
    • 50
    • 19
    Polyklonal
    Konjugat
    • 35
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IKZF1 Antikörper ist unkonjugiert
    Applikation
    • 50
    • 23
    • 21
    • 15
    • 12
    • 12
    • 7
    • 7
    • 6
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Verwendungszweck
    Anti-Ikaros/IKZF1 Antibody Picoband®
    Sequenz
    LKEEHRAYDL LRAASENSQD ALRVVSTSGE QM
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins
    Produktmerkmale
    Anti-Ikaros/IKZF1 Antibody Picoband® (ABIN3043860). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human Ikaros, different from the related mouse sequence by five amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product IKZF1 Primärantikörper
  • Applikationshinweise
    Western blot, 0.1-0.5 μg/mL, Human
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    1. Georgopoulos K, Moore DD, Derfler B (December 1992). "Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment". Science 258 (5083): 808-12. 2. Hahm K, Ernst P, Lo K, Kim GS, Turck C, Smale ST (November 1994). "The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene". Mol Cell Biol 14 (11): 7111-23.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target
    IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))
    Andere Bezeichnung
    IKZF1 (IKZF1 Produkte)
    Hintergrund

    Synonyms: DNA-binding protein Ikaros,Ikaros family zinc finger protein 1,Lymphoid transcription factor LyF-1,IKZF1,IK1, IKAROS, LYF1, ZNFN1A1,

    Tissue Specificity: Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine. .

    Background: DNA-binding protein Ikaros is a protein that in humans is encoded by the IKZF1 gene. This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors.

    Sequence Similarities: Contains 1 HMG box DNA-binding domain.

    Molekulargewicht
    50-70 kDa
    Gen-ID
    10320
    UniProt
    Q13422
    Pathways
    Production of Molecular Mediator of Immune Response
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