CD46 Antikörper (C-Term)

Produktnummer ABIN3043806

Produktdetails anti-CD46 Antikörper

Target: CD46

Bindungsspezifität: AA 366-392, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD46 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Membrane cofactor protein(CD46) detection. Tested with WB, IHC-P in Human.

Sequenz: YRYLQRRKKK GTYLTDETHR EVKFTSL

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Membrane cofactor protein(CD46) detection. Tested with WB, IHC-P in Human.
Gene Name: CD46 Molecule, complement regulatory protein
Protein Name: Membrane cofactor protein

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human CD46 (366-392aa YRYLQRRKKKGTYLTDETHREVKFTSL).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu CD46

Target: CD46

Andere Bezeichnung: CD46 (CD46 Produkte)

Synonyme: AHUS2 antikoerper, MCP antikoerper, MIC10 antikoerper, TLX antikoerper, TRA2.10 antikoerper, Mcp antikoerper, CD46 antikoerper, CD46 molecule antikoerper, CD46 antigen, complement regulatory protein antikoerper, CD46 molecule, complement regulatory protein antikoerper, membrane cofactor protein-like antikoerper, CD46 antikoerper, Cd46 antikoerper, LOC100341359 antikoerper, LOC103789310 antikoerper

Hintergrund: CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) and Membrane Cofactor Protein is a protein which in humans is encoded by the CD46 gene. The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. And the encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

Synonyms: AHUS2 antibody|Antigen defined by monoclonal antibody| TRA 2 10 antibody|Antigen identified by monoclonal antibody| TRA 2 10 antibody|CD46 antibody|CD46 antigen antibody|CD46 antigen complement regulatory protein antibody|CD46 Molecule antibody|CD46 Molecule complement regulatory protein antibody|Complement membrane cofactor protein antibody|MCP antibody| MCP_HUMAN antibody|Measles virus receptor antibody|membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen) antibody|Membrane cofactor protein antibody| MGC26544 antibody|MIC10 antibody|TLX antibody|TRA2.10 antibody|Trophoblast leucocyte common antigen antibody|Trophoblast leukocyte common antigen antibody|Trophoblast lymphocyte cross reactive antigen antibody

Gen-ID: 4179

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization