Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

Caveolin-1 Antikörper (AA 4-178)

Dieses Anti-Caveolin-1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Caveolin-1 in WB, IHC, IF, FACS und IHC (fro). Geeignet für Human, Ratte und Maus. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.
Produktnummer ABIN3043803

Kurzübersicht für Caveolin-1 Antikörper (AA 4-178) (ABIN3043803)

Target

Alle Caveolin-1 (CAV1) Antikörper anzeigen
Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))

Reaktivität

  • 117
  • 67
  • 50
  • 15
  • 11
  • 10
  • 9
  • 8
  • 8
  • 8
  • 5
  • 5
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Ratte, Maus

Wirt

  • 112
  • 19
  • 6
  • 2
  • 1
Kaninchen

Klonalität

  • 105
  • 35
Polyklonal

Konjugat

  • 103
  • 8
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Caveolin-1 Antikörper ist unkonjugiert

Applikation

  • 117
  • 53
  • 39
  • 34
  • 29
  • 28
  • 19
  • 16
  • 16
  • 9
  • 9
  • 4
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 15
    • 15
    • 8
    • 7
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 4-178

    Verwendungszweck

    Anti-Caveolin-1/CAV1 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-Caveolin-1/CAV1 Antibody Picoband® (ABIN3043803). Tested in Flow Cytometry, IF, IHC, IHC-F, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human Caveolin-1 recombinant protein (Position: G4-I178). Human Caveolin-1 shares 95% and 94% amino acid (aa) sequences identity with mouse and rat Caveolin-1, respectively.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse
    Immunohistochemistry (Frozen Section), 2-5 μg/mL, Human
    Immunofluorescence, 5 μg/mL, Human
    Flow Cytometry(Fixed), 1-3 μg/1x106 cells, Human1. Tahir, S. A., Yang, G., Ebara, S., Timme, T. L., Satoh, T., Li, L., Goltsov, A., Ittmann, M., Morrisett, J. D., Thompson, T. C.Secreted caveolin-1 stimulates cell survival/clonal growth and contributes to metastasis in androgen-insensitive prostate cancer.Cancer Res. 61: 3882-3885, 2001. 2. Wang, X. M., Zhang, Y., Kim, H. P., Zhou, Z., Feghali-Bostwick, C. A., Liu, F., Ifedigbo, E., Xu, X., Oury, T. D., Kaminski, N., Choi, A. M. K.Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis.J. Exp. Med. 203: 2895-2906, 2006. 3. Yang, G., Truong, L. D., Timme, T. L., Ren, C., Wheeler, T. M., Park, S. H., Nasu, Y., Bangma, C. H., Kattan, M. W., Scardino, P. T., Thompson, T. C.Elevated expression of caveolin is associated with prostate and breast cancer.Clin. Cancer Res. 4: 1873-1880, 1998.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F) and ICC.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Shi, Li, Jia, Ji, Song, Cheng, Wu, Song, Zhang, Zhu, Yang: "MicroRNA-199a-5p affects porcine preadipocyte proliferation and differentiation." in: International journal of molecular sciences, Vol. 15, Issue 5, pp. 8526-38, (2015) (PubMed).

    Wang, Zhao, Wu, He, Qu, Zhao, Zhao, Li, Wang: "Mechanistic analysis of taxol-induced multidrug resistance in an ovarian cancer cell line." in: Asian Pacific journal of cancer prevention : APJCP, Vol. 14, Issue 9, pp. 4983-8, (2013) (PubMed).

  • Target

    Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))

    Andere Bezeichnung

    CAV1

    Hintergrund

    Synonyms: Caveolin-1,CAV1,CAV,

    Tissue Specificity: Expressed in muscle and lung, less so in liver, brain and kidney.

    Background: CAV1 ( Caveolin-1) is a protein that in humans is encoded by the CAV1 gene. The CAV1 gene is mapped to 7q31.2. The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.

    Sequence Similarities: Belongs to the caveolin family.

    Molekulargewicht

    22 kDa

    Gen-ID

    857

    UniProt

    Q03135

    Pathways

    Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of Transporter Activity, VEGFR1 Specific Signals
Sie sind hier:
Chat with us!