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ALOX15 Antikörper (AA 2-337)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ALOX15 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.
Produktnummer ABIN3043726

Kurzübersicht für ALOX15 Antikörper (AA 2-337) (ABIN3043726)

Target

Alle ALOX15 Antikörper anzeigen
ALOX15 (Arachidonate 15-Lipoxygenase (ALOX15))

Reaktivität

  • 67
  • 25
  • 21
  • 2
  • 2
  • 2
  • 2
  • 1
Human, Ratte, Maus

Wirt

  • 54
  • 15
  • 1
Kaninchen

Klonalität

  • 55
  • 15
Polyklonal

Konjugat

  • 35
  • 8
  • 6
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ALOX15 Antikörper ist unkonjugiert

Applikation

  • 43
  • 25
  • 17
  • 13
  • 13
  • 13
  • 13
  • 11
  • 11
  • 8
  • 4
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 16
    • 12
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 2-337

    Verwendungszweck

    Anti-15 Lipoxygenase 1/ALOX15 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-15 Lipoxygenase 1/ALOX15 Antibody Picoband® (ABIN3043726). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human ALOX15 recombinant protein (Position: G2-P337). Human ALOX15 shares 72% and 73% amino acid (aa) sequences identity with mouse and rat ALOX15, respectively.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Mouse, Rat
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    1. Funk CD, Funk LB, FitzGerald GA, Samuelsson B (May 1992)."Characterization of human 12-lipoxygenase genes".Proceedings of the National Academy of Sciences of the United States of America 89 (9): 3962-6. 2. Kelavkar, U. P., Badr, K. F. Effects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12/15-lipoxygenase gene expression: evidence that 15-lipoxygenase is a mutator gene. Proc. Nat. Acad. Sci. 96: 4378-4383, 1999.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    ALOX15 (Arachidonate 15-Lipoxygenase (ALOX15))

    Andere Bezeichnung

    ALOX15

    Hintergrund

    Synonyms: Arachidonate 15-lipoxygenase,15-LOX,15-LOX-1,1.13.11.33,12/15-lipoxygenase,Arachidonate 12-lipoxygenase, leukocyte-type,12-LOX,1.13.11.31,Arachidonate omega-6 lipoxygenase,ALOX15,LOG15,

    Tissue Specificity: Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells. .

    Background: Arachidonate 15-lipoxygenase, also known as 15 LOX or LOG15, is an enzyme that in humans is encoded by the ALOX15 gene. This gene is mapped to 17p13.2. It is found that ALOX15 is a mutator gene. ALOX15 gene product is implicated in antiinflammation, membrane remodeling, and cancer development/metastasis. Loss of the TP53 gene, or gain-of-function activities resulting from the expression of its mutant forms regulates ALOX15 promoter activity in human and in mouse, albeit in ionally opposite manners.

    Sequence Similarities: Belongs to the lipoxygenase family.

    Molekulargewicht

    75 kDa

    Gen-ID

    246

    UniProt

    P16050

    Pathways

    Regulation of Actin Filament Polymerization
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