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ALOX15 Antikörper (AA 2-337)

ALOX15 Reaktivität: Human, Ratte, Maus WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3043726
  • Target Alle ALOX15 Antikörper anzeigen
    ALOX15 (Arachidonate 15-Lipoxygenase (ALOX15))
    Bindungsspezifität
    • 7
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 2-337
    Reaktivität
    • 40
    • 10
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 32
    • 10
    • 1
    Kaninchen
    Klonalität
    • 33
    • 10
    Polyklonal
    Konjugat
    • 23
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ALOX15 Antikörper ist unkonjugiert
    Applikation
    • 29
    • 14
    • 11
    • 10
    • 8
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Verwendungszweck
    Anti-15 Lipoxygenase 1/ALOX15 Antibody Picoband®
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins
    Produktmerkmale
    Anti-15 Lipoxygenase 1/ALOX15 Antibody Picoband® (ABIN3043726). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human ALOX15 recombinant protein (Position: G2-P337). Human ALOX15 shares 72% and 73% amino acid (aa) sequences identity with mouse and rat ALOX15, respectively.
    Isotyp
    IgG
    Top Product
    Discover our top product ALOX15 Primärantikörper
  • Applikationshinweise
    Western blot, 0.1-0.5 μg/mL, Mouse, Rat
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    1. Funk CD, Funk LB, FitzGerald GA, Samuelsson B (May 1992)."Characterization of human 12-lipoxygenase genes".Proceedings of the National Academy of Sciences of the United States of America 89 (9): 3962-6. 2. Kelavkar, U. P., Badr, K. F. Effects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12/15-lipoxygenase gene expression: evidence that 15-lipoxygenase is a mutator gene. Proc. Nat. Acad. Sci. 96: 4378-4383, 1999.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target
    ALOX15 (Arachidonate 15-Lipoxygenase (ALOX15))
    Andere Bezeichnung
    ALOX15 (ALOX15 Produkte)
    Hintergrund

    Synonyms: Arachidonate 15-lipoxygenase,15-LOX,15-LOX-1,1.13.11.33,12/15-lipoxygenase,Arachidonate 12-lipoxygenase, leukocyte-type,12-LOX,1.13.11.31,Arachidonate omega-6 lipoxygenase,ALOX15,LOG15,

    Tissue Specificity: Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells. .

    Background: Arachidonate 15-lipoxygenase, also known as 15 LOX or LOG15, is an enzyme that in humans is encoded by the ALOX15 gene. This gene is mapped to 17p13.2. It is found that ALOX15 is a mutator gene. ALOX15 gene product is implicated in antiinflammation, membrane remodeling, and cancer development/metastasis. Loss of the TP53 gene, or gain-of-function activities resulting from the expression of its mutant forms regulates ALOX15 promoter activity in human and in mouse, albeit in ionally opposite manners.

    Sequence Similarities: Belongs to the lipoxygenase family.

    Molekulargewicht
    75 kDa
    Gen-ID
    246
    UniProt
    P16050
    Pathways
    Regulation of Actin Filament Polymerization
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