ALOX15 Antikörper (AA 1-225)

Produktnummer ABIN7144538

Produktdetails anti-ALOX15 Antikörper

Target: ALOX15 (Arachidonate 15-Lipoxygenase (ALOX15))

Bindungsspezifität: AA 1-225

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALOX15 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Arachidonate 15-lipoxygenase protein (1-225AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu ALOX15

Target: ALOX15 (Arachidonate 15-Lipoxygenase (ALOX15))

Andere Bezeichnung: ALOX15 (ALOX15 Produkte)

Synonyme: 15-LOX-1 antikoerper, 15LOX-1 antikoerper, ALOX15 antikoerper, 12-LO antikoerper, Alox12l antikoerper, L-12LO antikoerper, 12-LOX antikoerper, Alox12 antikoerper, ALOX12 antikoerper, 15-LOX antikoerper, Alox12e antikoerper, arachidonate 15-lipoxygenase antikoerper, Arachidonate 15-lipoxygenase antikoerper, ALOX15 antikoerper, Alox15 antikoerper, Nmul_A0532 antikoerper, Sden_1680 antikoerper, Swoo_2919 antikoerper, PCC8801_3106 antikoerper, Cyan8802_3014 antikoerper, Nwat_1315 antikoerper

Hintergrund:

Background: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.

Aliases: 15 lipoxygenase 1 antibody, 15 LIPOXYGENASE RETICULOCYTE ARACHIDONATE antibody, 15 LOX antibody, 15 LOX 1 antibody, 15-LOX antibody, 15LOX 1 antibody, ALOX15 antibody, Arachidonate 15 lipoxygenase antibody, Arachidonate 15-lipoxygenase antibody, Arachidonate omega 6 lipoxygenase antibody, Arachidonate omega-6 lipoxygenase antibody, LOG15 antibody, LOX15_HUMAN antibody

UniProt: P16050

Pathways: Regulation of Actin Filament Polymerization