Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

ABI1 Antikörper (N-Term)

Dieses Anti-ABI1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ABI1 in WB, IHC, IF, FACS und ICC. Geeignet für Human, Ratte und Maus. Dieses Primary Antibody wurde in 1 Publikation zitiert.
Produktnummer ABIN3043515

Kurzübersicht für ABI1 Antikörper (N-Term) (ABIN3043515)

Target

Alle ABI1 Antikörper anzeigen
ABI1 (Abl-Interactor 1 (ABI1))

Reaktivität

  • 57
  • 44
  • 35
  • 9
  • 9
  • 8
  • 6
  • 6
  • 6
  • 6
  • 6
  • 4
  • 4
  • 2
  • 2
  • 1
  • 1
Human, Ratte, Maus

Wirt

  • 70
  • 4
Kaninchen

Klonalität

  • 70
  • 4
Polyklonal

Konjugat

  • 44
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ABI1 Antikörper ist unkonjugiert

Applikation

  • 55
  • 18
  • 17
  • 16
  • 14
  • 13
  • 13
  • 8
  • 7
  • 6
  • 4
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)
  • Bindungsspezifität

    • 15
    • 13
    • 8
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 151-175, N-Term

    Verwendungszweck

    Anti-SSH3BP1/ABI1 Antibody Picoband®

    Sequenz

    HGVKWLKAKH GNNQPARTGT LSRTN

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-SSH3BP1/ABI1 Antibody Picoband® (ABIN3043515). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the N-terminus of human ABI1, identical to the related mouse and rat sequences.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat
    Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    1. Tani, K., Sato, S., Sukezane, T., Kojima, H., Hirose, H., Hanafusa, H., Shishido, T. : Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian Enabled (Mena) by c-Abl kinase. J. Biol. Chem. 278: 21685-21692, 2003. 2. Taki, T., Shibuya, N., Taniwaki, M., Hanada, R., Morishita, K., Bessho, F., Yanagisawa, M., Hayashi, Y. : ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10,11)(p11.2,q23). Blood 92: 1125-1130, 1998.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Cui, Yu, Dong, Chen, Zhang, Liu: "Downregulation of ABI1 expression affects the progression and prognosis of human gastric carcinoma." in: Medical oncology (Northwood, London, England), Vol. 27, Issue 3, pp. 632-9, (2010) (PubMed).

  • Target

    ABI1 (Abl-Interactor 1 (ABI1))

    Andere Bezeichnung

    ABI1

    Hintergrund

    Synonyms: Abl interactor 1,Abelson interactor 1,Abi-1,Abl-binding protein 4,AblBP4,Eps8 SH3 domain-binding protein,Eps8-binding protein,Nap1-binding protein,Nap1BP,Spectrin SH3 domain-binding protein 1,e3B1,ABI1,SSH3BP1,

    Tissue Specificity: Widely expressed, with highest expression in brain. .

    Background: SSH3BP1 is also known as ABI1. ABI1 is a human homolog of mouse Abl-interactor-1 (Abi1), mapped on 10p11.2. ABI1 participates in the transduction of signals from Ras to Rac by regulating Rac-specific guanine nucleotide exchange factor (GEF) activities. It dramatically promoted ABL1-mediated tyrosine phosphorylation of MENA, but not of other substrates. Abi-1 regulates c-Abl-mediated phosphorylation of Mena by interacting with both proteins. ABI1 plays a role in the leukemogenesis by translocating to MLL.

    Sequence Similarities: Belongs to the ABI family.

    Molekulargewicht

    65 kDa

    Gen-ID

    10006

    Pathways

    RTK Signalweg, Response to Water Deprivation, ER-Nucleus Signaling
Sie sind hier:
Chat with us!