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Tuberin Antikörper (AA 1611-1807)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Tuberin in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.
Produktnummer ABIN3043498

Kurzübersicht für Tuberin Antikörper (AA 1611-1807) (ABIN3043498)

Target

Alle Tuberin (TSC2) Antikörper anzeigen
Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Reaktivität

  • 273
  • 179
  • 117
  • 8
  • 6
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 363
  • 13
Kaninchen

Klonalität

  • 350
  • 26
Polyklonal

Konjugat

  • 144
  • 32
  • 30
  • 29
  • 21
  • 21
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 6
  • 6
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
Dieser Tuberin Antikörper ist unkonjugiert

Applikation

  • 201
  • 169
  • 122
  • 81
  • 80
  • 61
  • 38
  • 33
  • 20
  • 14
  • 10
  • 7
  • 6
  • 5
  • 2
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 35
    • 23
    • 19
    • 19
    • 17
    • 16
    • 15
    • 15
    • 15
    • 11
    • 10
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1611-1807

    Verwendungszweck

    Anti-Tuberin/TSC2 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-Tuberin/TSC2 Antibody Picoband® (ABIN3043498). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human Tuberin recombinant protein (Position: H1611-V1807). Human Tuberin shares 94% and 90% amino acid (aa) sequences identity with mouse and rat Tuberin, respectively.

    Isotyp

    IgG
  • Applikationshinweise

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Western blot, 0.1-0.5 μg/mL, Human
    1. Chu-Shore, C. J., Major, P., Montenegro, M., Thiele, E. Cyst-like tubers are associated with TSC2 and epilepsy in tuberous sclerosis complex. Neurology 72: 1165-1169, 2009. 2. Jansen, F. E., Braams, O., Vincken, K. L., Algra, A., Anbeek, P., Jennekens-Schinkel, A., Halley, D., Zonnenberg, B. A., van den Ouweland, A., van Huffelen, A. C., van Nieuwenhuizen, O., Nellist, M. Overlapping neurologic and cognitive phenotypes in patients with TSC1 or TSC2 mutations. Neurology 70: 908-915, 2008.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

    Andere Bezeichnung

    TSC2

    Hintergrund

    Synonyms: Tuberin,Tuberous sclerosis 2 protein,TSC2,TSC4,

    Tissue Specificity: Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.

    Background: Tuberous sclerosis 2 protein, also known as TSC2 or Tuberin is a protein that is in humans. The chromosomal location of this gene is 16p13.3. Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. This gene involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. It stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro.

    Sequence Similarities: Contains 1 Rap-GAP domain.

    Molekulargewicht

    201 kDa

    Gen-ID

    7249

    UniProt

    P49815

    Pathways

    RTK Signalweg, AMPK Signaling, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus
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