Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

PAX6 Antikörper (Middle Region)

Der Kaninchen Polyklonal Anti-PAX6-Antikörper wurde für WB und IHC validiert. Er ist geeignet, PAX6 in Proben von Human, Maus und Ratte zu detektieren. Es ist 1 Publikation verfügbar.
Produktnummer ABIN3043379

Kurzübersicht für PAX6 Antikörper (Middle Region) (ABIN3043379)

Target

Alle PAX6 Antikörper anzeigen
PAX6 (Paired Box 6 (PAX6))

Reaktivität

  • 115
  • 73
  • 72
  • 16
  • 7
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 93
  • 45
  • 1
Kaninchen

Klonalität

  • 79
  • 59
Polyklonal

Konjugat

  • 77
  • 7
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser PAX6 Antikörper ist unkonjugiert

Applikation

  • 96
  • 50
  • 50
  • 40
  • 32
  • 26
  • 16
  • 13
  • 12
  • 9
  • 8
  • 8
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 29
    • 24
    • 16
    • 15
    • 10
    • 8
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 195-233, Middle Region

    Verwendungszweck

    Anti-PAX6 Antibody Picoband®

    Sequenz

    EDSDEAQMRL QLKRKLQRNR TSFTQEQIEA LEKEFERTH

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-PAX6 Antibody Picoband® (ABIN3043379). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence in the middle region of human PAX6, identical to the related mouse and rat sequences.

    Isotyp

    IgG
  • Applikationshinweise

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    1. Gehring WJ, Ikeo K (September 1999). "Pax 6: mastering eye morphogenesis and eye evolution". Trends Genet. 15 (9): 371-7. 2. Jordan T, Hanson I, Zaletayev D, Hodgson S, Prosser J, Seawright A, Hastie N, van Heyningen V (August 1992). "The human PAX6 gene is mutated in two patients with aniridia". Nat. Genet. 1 (5): 328-32. 3. Walcher T, Xie Q, Sun J, Irmler M, Beckers J, 79ztürk T, Niessing D, Stoykova A, Cvekl A, Ninkovic J, Götz M (March 2013). "Functional dissection of the paired domain of Pax6 reveals molecular mechanisms of coordinating neurogenesis and proliferation". Development 140 (5): 1123-36.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Liu, Novak, Pepin, Maschhoff, Worner, Chen, Zhang, Hu: "A congenital hydrocephalus-causing mutation in Trim71 induces stem cell defects via inhibiting Lsd1 mRNA translation." in: EMBO reports, Vol. 24, Issue 2, pp. e55843, (2023) (PubMed).

  • Target

    PAX6 (Paired Box 6 (PAX6))

    Andere Bezeichnung

    PAX6

    Hintergrund

    Synonyms: Paired box protein Pax-6,Aniridia type II protein,Oculorhombin,PAX6,AN2,

    Tissue Specificity: Fetal eye, brain, spinal cord and olfactory epithelium. Isoform 5a is less abundant than the PAX6 shorter form.

    Background: Paired box protein Pax-6, also known as aniridia type II protein (AN2) or oculorhombin, is a protein that in humans is encoded by the PAX6 gene. This gene encodes a homeobox and paired domain-containing protein that binds DNA and functions as a regulator of transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. In addition, this gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms.

    Molekulargewicht

    47 kDa

    Gen-ID

    5080

    UniProt

    P26367

    Pathways

    Peptide Hormone Metabolism, Carbohydrate Homeostasis
Sie sind hier:
Chat with us!