SOCS4 Antikörper (AA 291-440)

Produktnummer ABIN3043346

Der Kaninchen Polyklonal Anti-SOCS4-Antikörper wurde für WB validiert. Er ist geeignet, SOCS4 in Proben von Human zu detektieren.

Kurzübersicht für SOCS4 Antikörper (AA 291-440) (ABIN3043346)

Target: SOCS4 (Suppressor of Cytokine Signaling 4 (SOCS4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SOCS4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SOCS4 Antikörper

Bindungsspezifität: AA 291-440

Verwendungszweck: Anti-SOCS4 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-SOCS4 Antibody Picoband® (ABIN3043346). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human SOCS4 recombinant protein (Position: M291-C440). Human SOCS4 shares 98% amino acid (aa) sequence identity with mouse SOCS4.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human
1. Bullock AN, Rodriguez MC, Debreczeni JE, Songyang Z, Knapp S. ""Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation"". Structure, 2007 Nov. 2. Kobayashi D, Nomoto S, Kodera Y, Fujiwara M, Koike M, Nakayama G, Ohashi N, Nakao A. ""Suppressor of cytokine signaling 4 detected as a novel gastric cancer suppressor gene using double combination array analysis"". World J Surg, 2012 Feb.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu SOCS4

Target: SOCS4 (Suppressor of Cytokine Signaling 4 (SOCS4))

Andere Bezeichnung: SOCS4

Hintergrund:

Synonyms: Suppressor of cytokine signaling 4,SOCS-4,Suppressor of cytokine signaling 7,SOCS-7,SOCS4,SOCS7,

Tissue Specificity: Placenta, liver, and to a much smaller extent, in lung.

Background: SOCS4, also known as Suppressor of cytokine signaling 4, is mapped to 14q22.1. The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Sequence Similarities: Contains 1 SH2 domain.

Molekulargewicht: 51 kDa

Gen-ID: 122809

Pathways: JAK-STAT Signalweg, EGFR Signaling Pathway