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GLI2 Antikörper (C-Term)

GLI2 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Pubmed (1 reference)
Produktnummer ABIN3042988
$315.00
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 4 bis 6 Werktagen
  • Target Alle GLI2 Antikörper anzeigen
    GLI2 (GLI Family Zinc Finger 2 (GLI2))
    Bindungsspezifität
    • 10
    • 7
    • 7
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1444-1463, C-Term
    Reaktivität
    • 46
    • 14
    • 6
    • 2
    • 2
    • 1
    Human
    Wirt
    • 40
    • 7
    • 2
    Kaninchen
    Klonalität
    • 47
    • 2
    Polyklonal
    Konjugat
    • 19
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Dieser GLI2 Antikörper ist unkonjugiert
    Applikation
    • 18
    • 17
    • 10
    • 5
    • 5
    • 3
    • 1
    Western Blotting (WB)
    Verwendungszweck
    Rabbit IgG polyclonal antibody for Zinc finger protein GLI2(GLI2) detection. Tested with WB in Human.
    Sequenz
    MLYYYGQIHM YEQDGGLENL
    Kreuzreaktivität (Details)
    No cross reactivity with other proteins.
    Produktmerkmale
    Rabbit IgG polyclonal antibody for Zinc finger protein GLI2(GLI2) detection. Tested with WB in Human.
    Gene Name: GLI family zinc finger 2
    Protein Name: Zinc finger protein GLI2
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human Gli2(1444-1463aa MLYYYGQIHMYEQDGGLENL).
    Isotyp
    IgG
  • Applikationshinweise
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for GLI2 is approximately 0.5 ng/lane under reducing conditions.
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Vorsichtsmaßnahmen
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    Haltbarkeit
    12 months
  • Xiang, Jiang, Guo, Gong, Yang, Wu, Huang, Cheng, Xu: "Hedgehog pathway inhibitor-4 suppresses malignant properties of chondrosarcoma cells by disturbing tumor ciliogenesis." in: Oncology reports, Vol. 32, Issue 4, pp. 1622-30, (2014) (PubMed).

  • Target
    GLI2 (GLI Family Zinc Finger 2 (GLI2))
    Andere Bezeichnung
    GLI2 (GLI2 Produkte)
    Synonyme
    HPE9, THP1, THP2, GLI2/GLI4, GLI3, AW546128, GLI family zinc finger 2, GLI-Kruppel family member GLI2, GLI2, Gli2
    Hintergrund
    GLI2(Gli-Kruppel Family Member 2), also called ONCOGENE GLI2, is a protein that in humans is encoded by the GLI2 gene. Sequencing of GLI cDNA clones showed the presence of 5 tandem zinc fingers connected by histidine-cysteine links, which indicated that the gene belongs to the family of zinc finger genes related to Kruppel(Kr). The Drosophila gene Kr is a member of the gap class of segmentation genes, thoracic and anterior abdominal segments fail to form in Kr mutant embryos. By fluorescence in situ hybridization, Matsumoto et al.(1996) refined the assignment of the GLI2 gene to chromosome 2q14. Roessler et al.(2005) showed that GLI2-delta-N exhibited potent transcriptional activity in vivo: overexpression in mouse skin led to the formation of hedgehog-independent epithelial downgrowths resembling basal cell carcinomas, which in humans are associated with constitutive hedgehog signaling.

    Synonyms: Gli 2 antibody|GLI family zinc finger 2 antibody|GLI kruppel family member 2 antibody|GLI Kruppel family member GLI2 antibody|GLI2 antibody|GLI2_HUMAN antibody|Oncogene GLI2 antibody|Tax helper protein antibody|Tax helper protein 2 antibody|Tax responsive element 2 holding protein antibody|Tax responsive element 25 bp sequence binding protein antibody|THP 2 antibody|THP antibody|THP2 antibody|Zinc finger protein GLI2 antibody
    UniProt
    P10070
    Pathways
    Hedgehog Signalweg, Dopaminergic Neurogenesis
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